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- W2152001406 abstract "Pneumonia, a common disease caused by a great diversity of infectious agents is responsible for enormous morbidity and mortality worldwide. The bronchial and lung epithelium comprises a large surface between host and environment and is attacked as a primary target during lung infection. Besides acting as a mechanical barrier, recent evidence suggests that the lung epithelium functions as an important sentinel system against pathogens. Equipped with transmembranous and cytosolic pathogen-sensing pattern recognition receptors the epithelium detects invading pathogens. A complex signalling results in epithelial cell activation, which essentially participates in initiation and orchestration of the subsequent innate and adaptive immune response. In this review we summarize recent progress in research focussing on molecular mechanisms of pathogen detection, host cell signal transduction, and subsequent activation of lung epithelial cells by pathogens and their virulence factors and point to open questions. The analysis of lung epithelial function in the host response in pneumonia may pave the way to the development of innovative highly needed therapeutics in pneumonia in addition to antibiotics." @default.
- W2152001406 created "2016-06-24" @default.
- W2152001406 creator A5017328820 @default.
- W2152001406 creator A5031735316 @default.
- W2152001406 creator A5040973193 @default.
- W2152001406 creator A5070409333 @default.
- W2152001406 date "2006-07-08" @default.
- W2152001406 modified "2023-10-16" @default.
- W2152001406 title "Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen recognition and signal transduction" @default.
- W2152001406 cites W1499978168 @default.
- W2152001406 cites W1501181174 @default.
- W2152001406 cites W1502147118 @default.
- W2152001406 cites W1507312398 @default.
- W2152001406 cites W1512595753 @default.
- W2152001406 cites W1514224413 @default.
- W2152001406 cites W1514540900 @default.
- W2152001406 cites W1519633296 @default.
- W2152001406 cites W1519835538 @default.
- W2152001406 cites W1520365933 @default.
- W2152001406 cites W1536952772 @default.
- W2152001406 cites W1557965441 @default.
- W2152001406 cites W1592851115 @default.
- W2152001406 cites W1593402425 @default.
- W2152001406 cites W1598802044 @default.
- W2152001406 cites W1833951784 @default.
- W2152001406 cites W1839029331 @default.
- W2152001406 cites W1857340119 @default.
- W2152001406 cites W1943200863 @default.
- W2152001406 cites W1954121192 @default.
- W2152001406 cites W1963559583 @default.
- W2152001406 cites W1964343287 @default.
- W2152001406 cites W1964854788 @default.
- W2152001406 cites W1964982019 @default.
- W2152001406 cites W1965202893 @default.
- W2152001406 cites W1966166051 @default.
- W2152001406 cites W1966523994 @default.
- W2152001406 cites W1966772446 @default.
- W2152001406 cites W1967269498 @default.
- W2152001406 cites W1968215289 @default.
- W2152001406 cites W1968259615 @default.
- W2152001406 cites W1969072247 @default.
- W2152001406 cites W1969430178 @default.
- W2152001406 cites W1969457486 @default.
- W2152001406 cites W1970743383 @default.
- W2152001406 cites W1972093499 @default.
- W2152001406 cites W1972285445 @default.
- W2152001406 cites W1973209498 @default.
- W2152001406 cites W1977971835 @default.
- W2152001406 cites W1978458547 @default.
- W2152001406 cites W1979781669 @default.
- W2152001406 cites W1980168760 @default.
- W2152001406 cites W1980401334 @default.
- W2152001406 cites W1981348723 @default.
- W2152001406 cites W1981837371 @default.
- W2152001406 cites W1983664771 @default.
- W2152001406 cites W1984450450 @default.
- W2152001406 cites W1985201059 @default.
- W2152001406 cites W1985254980 @default.
- W2152001406 cites W1986997900 @default.
- W2152001406 cites W1987180471 @default.
- W2152001406 cites W1988347181 @default.
- W2152001406 cites W1988700176 @default.
- W2152001406 cites W1989656760 @default.
- W2152001406 cites W1990325593 @default.
- W2152001406 cites W1993377613 @default.
- W2152001406 cites W1994391392 @default.
- W2152001406 cites W1994396536 @default.
- W2152001406 cites W1996120614 @default.
- W2152001406 cites W1997001575 @default.
- W2152001406 cites W1997883562 @default.
- W2152001406 cites W2000175632 @default.
- W2152001406 cites W2000229886 @default.
- W2152001406 cites W2002698073 @default.
- W2152001406 cites W2002876696 @default.
- W2152001406 cites W2004465286 @default.
- W2152001406 cites W2005148035 @default.
- W2152001406 cites W2008145382 @default.
- W2152001406 cites W2008315458 @default.
- W2152001406 cites W2008390343 @default.
- W2152001406 cites W2008759459 @default.
- W2152001406 cites W2009364588 @default.
- W2152001406 cites W2010453472 @default.
- W2152001406 cites W2010846919 @default.
- W2152001406 cites W2012193854 @default.
- W2152001406 cites W2016292931 @default.
- W2152001406 cites W2016503643 @default.
- W2152001406 cites W2017883909 @default.
- W2152001406 cites W2018542503 @default.
- W2152001406 cites W2018584780 @default.
- W2152001406 cites W2018828712 @default.
- W2152001406 cites W2019997936 @default.
- W2152001406 cites W2020724339 @default.
- W2152001406 cites W2021068575 @default.
- W2152001406 cites W2022175069 @default.
- W2152001406 cites W2022407885 @default.
- W2152001406 cites W2022600374 @default.
- W2152001406 cites W2025983848 @default.
- W2152001406 cites W2026644722 @default.
- W2152001406 cites W2028001141 @default.
- W2152001406 cites W2028220671 @default.