Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152046668> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2152046668 endingPage "568" @default.
- W2152046668 startingPage "565" @default.
- W2152046668 abstract "The authors have shown direct, real-time, in vivo measurement of nitric oxide (NO) in mice by using the water soluble metal chelator complex, N-methyl-D-glucamine dithiocarbamate (MGD), and Fe(II) as monitored by EPR at L-band. The three-line EPR spectrum from the product [(MGD)2-Fe(II)-NO] was observed noninvasively in lipopolysaccharide (LPS)-treated mice. The spectrum was markedly suppressed by the administration, before LPS injection, of phenyl N-tert-butyl nitrone (PBN), an inhibitor of the expression of induced nitric oxide synthase (iNOS). When 15N-arginine was administered to LPS-treated mice, a diagnostic EPR spectrum was observed, consisting of both three- and two-line EPR signals, due to (MGD)2-Fe(II)-14NO and (MGD)2-Fe(II)-15NO, respectively. The results strongly suggested that the NO detected in these experiments was synthesized by iNOS. In vivo EPR measurements of [(MGD)2-Fe(II)-NO] at several regions in the body (from the head to the tail) indicated that the NO was generated mostly in the upper abdomen near the liver. These observations were confirmed by ex vivo EPR measurements on isolated organs where higher NO levels were detected in vivo in the liver and kidney. The spectroscopic results, combined with the pharmacokinetic data, support the model that NO detected in LPS-treated mice was produced mainly in the liver, and that it did not reflect NO-adduct complex accumulated in the liver via the blood circulation." @default.
- W2152046668 created "2016-06-24" @default.
- W2152046668 creator A5013008419 @default.
- W2152046668 creator A5030972411 @default.
- W2152046668 creator A5042749170 @default.
- W2152046668 date "1997-10-01" @default.
- W2152046668 modified "2023-10-17" @default.
- W2152046668 title "Determination and characterization of nitric oxide generation in mice byin vivo l-band EPR spectroscopy" @default.
- W2152046668 cites W1490576088 @default.
- W2152046668 cites W1541963905 @default.
- W2152046668 cites W1834041853 @default.
- W2152046668 cites W1974256277 @default.
- W2152046668 cites W1976271098 @default.
- W2152046668 cites W1981787640 @default.
- W2152046668 cites W1987166207 @default.
- W2152046668 cites W1991984561 @default.
- W2152046668 cites W1994950364 @default.
- W2152046668 cites W2041473312 @default.
- W2152046668 cites W2053559929 @default.
- W2152046668 cites W2062316787 @default.
- W2152046668 cites W2069347285 @default.
- W2152046668 doi "https://doi.org/10.1002/mrm.1910380410" @default.
- W2152046668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9324323" @default.
- W2152046668 hasPublicationYear "1997" @default.
- W2152046668 type Work @default.
- W2152046668 sameAs 2152046668 @default.
- W2152046668 citedByCount "59" @default.
- W2152046668 countsByYear W21520466682012 @default.
- W2152046668 countsByYear W21520466682016 @default.
- W2152046668 countsByYear W21520466682017 @default.
- W2152046668 countsByYear W21520466682018 @default.
- W2152046668 crossrefType "journal-article" @default.
- W2152046668 hasAuthorship W2152046668A5013008419 @default.
- W2152046668 hasAuthorship W2152046668A5030972411 @default.
- W2152046668 hasAuthorship W2152046668A5042749170 @default.
- W2152046668 hasConcept C108204754 @default.
- W2152046668 hasConcept C121332964 @default.
- W2152046668 hasConcept C13965031 @default.
- W2152046668 hasConcept C150903083 @default.
- W2152046668 hasConcept C178790620 @default.
- W2152046668 hasConcept C185592680 @default.
- W2152046668 hasConcept C187961010 @default.
- W2152046668 hasConcept C207001950 @default.
- W2152046668 hasConcept C2777622882 @default.
- W2152046668 hasConcept C46141821 @default.
- W2152046668 hasConcept C519581460 @default.
- W2152046668 hasConcept C86803240 @default.
- W2152046668 hasConceptScore W2152046668C108204754 @default.
- W2152046668 hasConceptScore W2152046668C121332964 @default.
- W2152046668 hasConceptScore W2152046668C13965031 @default.
- W2152046668 hasConceptScore W2152046668C150903083 @default.
- W2152046668 hasConceptScore W2152046668C178790620 @default.
- W2152046668 hasConceptScore W2152046668C185592680 @default.
- W2152046668 hasConceptScore W2152046668C187961010 @default.
- W2152046668 hasConceptScore W2152046668C207001950 @default.
- W2152046668 hasConceptScore W2152046668C2777622882 @default.
- W2152046668 hasConceptScore W2152046668C46141821 @default.
- W2152046668 hasConceptScore W2152046668C519581460 @default.
- W2152046668 hasConceptScore W2152046668C86803240 @default.
- W2152046668 hasIssue "4" @default.
- W2152046668 hasLocation W21520466681 @default.
- W2152046668 hasLocation W21520466682 @default.
- W2152046668 hasOpenAccess W2152046668 @default.
- W2152046668 hasPrimaryLocation W21520466681 @default.
- W2152046668 hasRelatedWork W1598394707 @default.
- W2152046668 hasRelatedWork W1987166207 @default.
- W2152046668 hasRelatedWork W2038940888 @default.
- W2152046668 hasRelatedWork W2040721011 @default.
- W2152046668 hasRelatedWork W2072134682 @default.
- W2152046668 hasRelatedWork W2085967611 @default.
- W2152046668 hasRelatedWork W2152046668 @default.
- W2152046668 hasRelatedWork W2256974744 @default.
- W2152046668 hasRelatedWork W2400723190 @default.
- W2152046668 hasRelatedWork W2406574576 @default.
- W2152046668 hasVolume "38" @default.
- W2152046668 isParatext "false" @default.
- W2152046668 isRetracted "false" @default.
- W2152046668 magId "2152046668" @default.
- W2152046668 workType "article" @default.