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- W2152059213 abstract "The proof of concept that proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition affects cholesterol levels was first established after the demonstration that PCSK9 loss-of-function mutations result in a significant drop in circulating LDL cholesterol levels. Subsequent studies revealed that PCSK9 binds the epidermal growth factor precursor homology domain-A on the surface LDL Receptor (LDLR) and directs LDLR and PCSK9 for lysosomal degradation. Alirocumab (also known as SAR236553/REGN727) is a monoclonal antibody that binds circulating PCSK9 and blocks its interactions with surface LDLR. Alirocumab clinical trials with different doses on different administration schedules were shown to significantly reduce LDL cholesterol both as a mono-therapy and in combination with statins or ezetimibe. Although there is great potential for anti-PCSK9 therapies in the management of cholesterol metabolism, there is no clear evidence yet that blocking PCSK9 reduces cardiovascular disease outcome. This is being investigated in ongoing Phase III clinical trials with alirocumab." @default.
- W2152059213 created "2016-06-24" @default.
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- W2152059213 creator A5068826784 @default.
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- W2152059213 date "2014-09-22" @default.
- W2152059213 modified "2023-09-24" @default.
- W2152059213 title "Alirocumab: PCSK9 inhibitor for LDL cholesterol reduction" @default.
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- W2152059213 doi "https://doi.org/10.1586/14779072.2014.954551" @default.
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