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- W2152091016 abstract "Abstract cJun NH2-terminal kinase (JNK) signaling has been implicated in the developmental morphogenesis of epithelial organs. In this study, we employed a compound deletion of the murine Jnk1 and Jnk2 genes in the mammary gland to evaluate the requirement for these ubiquitously expressed genes in breast development and tumorigenesis. JNK1/2 was not required for breast epithelial cell proliferation or motility. However, JNK1/2 deficiency caused increased branching morphogenesis and defects in the clearance of lumenal epithelial cells. In the setting of breast cancer development, JNK1/2 deficiency significantly increased tumor formation. Together, these findings established that JNK signaling is required for normal mammary gland development and that it has a suppressive role in mammary tumorigenesis. Cancer Res; 72(2); 472–81. ©2011 AACR." @default.
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- W2152091016 date "2012-01-15" @default.
- W2152091016 modified "2023-10-01" @default.
- W2152091016 title "Role of JNK in Mammary Gland Development and Breast Cancer" @default.
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- W2152091016 doi "https://doi.org/10.1158/0008-5472.can-11-1628" @default.
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