FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152106875> ?p ?o ?g. }

• W2152106875 endingPage "74" @default.
• W2152106875 startingPage "67" @default.
• W2152106875 abstract "Primary pigmented nodular adrenocortical disease (PPNAD) can lead to steroid hormone overproduction. Mutations in the cAMP protein kinase A regulatory subunit type 1A (PRKAR1A) are causative of PPNAD. Steroidogenesis in PPNAD can be modified through a local glucocorticoid feed-forward loop.Investigation of regulation of steroidogenesis in a case of PPNAD with virilization.A 33-year-old woman presented with primary infertility due to hyperandrogenism. Elevated levels of testosterone and subclinical ACTH-independent Cushing's syndrome led to the discovery of an adrenal tumor, which was diagnosed as PPNAD. In vivo evaluation of aberrantly expressed hormone receptors showed no steroid response to known stimuli. Genetic analysis revealed a PRKAR1A protein-truncating Q28X mutation. After adrenalectomy, steroid levels normalized. Tumor cells were cultured and steroidogenic responses to ACTH and dexamethasone were measured and compared with those in normal adrenal and adrenocortical carcinoma cells. Expression levels of 17β-hydroxysteroid dehydrogenase (17β-HSD) types 3 and 5 and steroid receptors were quantified in PPNAD, normal adrenal, and adrenal adenoma tissues.Isolated PPNAD cells, analogous to normal adrenal cells, showed both increased steroidogenic enzyme expression and steroid secretion in response to ACTH. Dexamethasone did not affect steroid production in the investigated types of adrenal cells. 17β-HSD type 5 was expressed at a higher level in the PPNAD-associated adenoma compared with control adrenal tissue.PPNAD-associated adenomas can cause virilization and infertility by adrenal androgen overproduction. This may be due to steroidogenic control mechanisms that differ from those described for PPNAD without large adenomas." @default.
• W2152106875 created "2016-06-24" @default.
• W2152106875 creator A5003004438 @default.
• W2152106875 creator A5006066076 @default.
• W2152106875 creator A5006159770 @default.
• W2152106875 creator A5023302477 @default.
• W2152106875 creator A5030754052 @default.
• W2152106875 creator A5031897654 @default.
• W2152106875 creator A5040710891 @default.
• W2152106875 creator A5048006075 @default.
• W2152106875 creator A5059720767 @default.
• W2152106875 creator A5087549185 @default.
• W2152106875 creator A5088231475 @default.
• W2152106875 date "2013-01-01" @default.
• W2152106875 modified "2023-09-26" @default.
• W2152106875 title "Regulation of steroidogenesis in a primary pigmented nodular adrenocortical disease-associated adenoma leading to virilization and subclinical Cushing's syndrome" @default.
• W2152106875 cites W1968621017 @default.
• W2152106875 cites W1983878028 @default.
• W2152106875 cites W1986479120 @default.
• W2152106875 cites W2004666578 @default.
• W2152106875 cites W2008227227 @default.
• W2152106875 cites W2009917029 @default.
• W2152106875 cites W2019488062 @default.
• W2152106875 cites W2025351096 @default.
• W2152106875 cites W2037923746 @default.
• W2152106875 cites W2038319066 @default.
• W2152106875 cites W2041411519 @default.
• W2152106875 cites W2061134758 @default.
• W2152106875 cites W2089127970 @default.
• W2152106875 cites W2094923832 @default.
• W2152106875 cites W2095849867 @default.
• W2152106875 cites W2099477169 @default.
• W2152106875 cites W2117535295 @default.
• W2152106875 cites W2124127909 @default.
• W2152106875 cites W2127529986 @default.
• W2152106875 cites W2133043734 @default.
• W2152106875 cites W2143399308 @default.
• W2152106875 cites W2157610967 @default.
• W2152106875 cites W2159641345 @default.
• W2152106875 cites W2160467994 @default.
• W2152106875 cites W2162041524 @default.
• W2152106875 cites W4236489741 @default.
• W2152106875 cites W4237155360 @default.
• W2152106875 doi "https://doi.org/10.1530/eje-12-0594" @default.
• W2152106875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4100689" @default.
• W2152106875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23065993" @default.
• W2152106875 hasPublicationYear "2013" @default.
• W2152106875 type Work @default.
• W2152106875 sameAs 2152106875 @default.
• W2152106875 citedByCount "13" @default.
• W2152106875 countsByYear W21521068752012 @default.
• W2152106875 countsByYear W21521068752013 @default.
• W2152106875 countsByYear W21521068752015 @default.
• W2152106875 countsByYear W21521068752016 @default.
• W2152106875 countsByYear W21521068752017 @default.
• W2152106875 countsByYear W21521068752018 @default.
• W2152106875 countsByYear W21521068752019 @default.
• W2152106875 countsByYear W21521068752021 @default.
• W2152106875 countsByYear W21521068752022 @default.
• W2152106875 crossrefType "journal-article" @default.
• W2152106875 hasAuthorship W2152106875A5003004438 @default.
• W2152106875 hasAuthorship W2152106875A5006066076 @default.
• W2152106875 hasAuthorship W2152106875A5006159770 @default.
• W2152106875 hasAuthorship W2152106875A5023302477 @default.
• W2152106875 hasAuthorship W2152106875A5030754052 @default.
• W2152106875 hasAuthorship W2152106875A5031897654 @default.
• W2152106875 hasAuthorship W2152106875A5040710891 @default.
• W2152106875 hasAuthorship W2152106875A5048006075 @default.
• W2152106875 hasAuthorship W2152106875A5059720767 @default.
• W2152106875 hasAuthorship W2152106875A5087549185 @default.
• W2152106875 hasAuthorship W2152106875A5088231475 @default.
• W2152106875 hasBestOaLocation W21521068751 @default.
• W2152106875 hasConcept C126322002 @default.
• W2152106875 hasConcept C134018914 @default.
• W2152106875 hasConcept C2776631543 @default.
• W2152106875 hasConcept C2777391703 @default.
• W2152106875 hasConcept C2777428134 @default.
• W2152106875 hasConcept C2777911890 @default.
• W2152106875 hasConcept C2778674399 @default.
• W2152106875 hasConcept C2778914232 @default.
• W2152106875 hasConcept C2780186808 @default.
• W2152106875 hasConcept C2781399356 @default.
• W2152106875 hasConcept C3018442814 @default.
• W2152106875 hasConcept C555293320 @default.
• W2152106875 hasConcept C71315377 @default.
• W2152106875 hasConcept C71924100 @default.
• W2152106875 hasConcept C86803240 @default.
• W2152106875 hasConceptScore W2152106875C126322002 @default.
• W2152106875 hasConceptScore W2152106875C134018914 @default.
• W2152106875 hasConceptScore W2152106875C2776631543 @default.
• W2152106875 hasConceptScore W2152106875C2777391703 @default.
• W2152106875 hasConceptScore W2152106875C2777428134 @default.
• W2152106875 hasConceptScore W2152106875C2777911890 @default.
• W2152106875 hasConceptScore W2152106875C2778674399 @default.
• W2152106875 hasConceptScore W2152106875C2778914232 @default.
• W2152106875 hasConceptScore W2152106875C2780186808 @default.
• W2152106875 hasConceptScore W2152106875C2781399356 @default.
• W2152106875 hasConceptScore W2152106875C3018442814 @default.

• next