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• W2152109750 abstract "In this study, the putative antidiabetic effect of garlic was re-investigated. Aqueous crude garlic solution was prepared at high concentration (2 g/ml) and extracts were obtained by ethanol precipitation followed by chromatography on C18 Sep-Pak cartridge. Garlic or extracts were administered by single intraperitoneal injection to euglycaemic rats. Plasma glucose, insulin and nitric oxide (NO) were determined after 30 min, 1 and 2 h, respectively. Garlic induced hypoglycemia and hyperinsulinemia which is mimicked by an ethanol soluble and non polar extract. This active principle appeared different from S-allyl-cystein sulfoxide based on physico-chemical properties and mode of action. Data of thin layer chromatography experiments indicated the presence of at least four molecular species, indicating a more non polar nature, with Rf values higher than S-allyl-cystein sulfoxide. The mechanism of action seemed to involve nitric oxide as its glucose induced lowering activity is abolished by diphenyleneiodonium which is a selective constitutive nitric oxide synthase inhibitor. Key words: Garlic, Plasma Glucose, Insulinemia, Nitric Oxide, Thin Layer Chromatography." @default.
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• W2152109750 date "2013-08-15" @default.
• W2152109750 modified "2023-09-22" @default.
• W2152109750 title "Acute modulation of rat plasma glucose byan aqueous garlic extract" @default.
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• W2152109750 doi "https://doi.org/10.5897/ajpp2013.3510" @default.
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