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- W2152111514 abstract "A review of the international literature has revealed 68 paragangliomas, 42 large cell, and 74 small cell tumors of the larynx. Paragangliomas are usually benign, although malignant cases have been reported. Large cell tumors are malignancies associated with a high incidence of early cervical metastasis. Small cell tumors are aggressive cancers characterized by early, diffuse metastatic disease. All three neoplasms demonstrate a propensity for the supraglottic larynx. While surgery remains the treatment of choice for paragangliomas and large cell cancers, small cell cancers are best treated by radiotherapy and chemotherapy. The determinate 5-year survival for patients with paragangliomas, large cell, and small cell cancers is 60%, 34%, and 14%, respectively. While representing distinct clinical entities, these neoplasms demonstrate similar ultrastructural and histochemical features and should be classified as neuroendocrine tumors of the larynx (NETL). A comprehensive analysis of these laryngeal tumors is presented herein. Their clinical behavior and management options are reviewed and a scheme for their nomenclature and classification is proposed." @default.
- W2152111514 created "2016-06-24" @default.
- W2152111514 creator A5005738788 @default.
- W2152111514 date "1991-11-01" @default.
- W2152111514 modified "2023-10-18" @default.
- W2152111514 title "Neuroendocrine tumors of the larynx" @default.
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- W2152111514 doi "https://doi.org/10.1002/hed.2880130605" @default.
- W2152111514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1665150" @default.
- W2152111514 hasPublicationYear "1991" @default.
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