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- W2152121254 abstract "Ethology, the biology of behaviour, is briefly introduced, and a review is presented of two ethological methods applied to toxicology. (1) When elements in the behaviour of rats in a social situation are objectively observed, chemically-induced changes in several kinds of behaviour can be detected at low doses. Changes are specific and repeatable in long-term experiments. Effects of nicotine at a 'smoking' dose, or trichloroethylene at the Threshold Limit Value, were reversible; limited tolerance developed to methyl mercury dicyandiamide. (2) An 'Exploration-Thirst' method is simple enough for use as a screen. It was compared with conventional toxicological methods for 30 compounds in routine screening (20 acute intraperitoneal, 10 subacute inhalation). Both ethological methods are sensitive enough to estimate 'no-effect' doses. They also distinguish non-specific toxic effects (consistent with the animal's equivalent of 'feeling ill') from various more specific CNS effects comparable to those of human experience." @default.
- W2152121254 created "2016-06-24" @default.
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- W2152121254 date "1988-03-01" @default.
- W2152121254 modified "2023-09-25" @default.
- W2152121254 title "An ethologist's approach to behavioural toxicology" @default.
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- W2152121254 doi "https://doi.org/10.1016/0892-0362(88)90071-2" @default.
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