Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152125093> ?p ?o ?g. }
- W2152125093 endingPage "1401" @default.
- W2152125093 startingPage "1379" @default.
- W2152125093 abstract "Advances in stem cell biology have raised great expectations that diseases and injuries of the central nervous system (CNS) may be ameliorated by the development of non-hematopoietic stem cell medicines. Yet, the application of adult stem cells as CNS therapeutics is challenging and the interpretation of some of the outcomes ambiguous. In fact, the initial idea that stem cell transplants work only via structural cell replacement has been challenged by the observation of consistent cellular signaling between the graft and the host. Cellular signaling is the foundation of coordinated actions and flexible responses, and arises via networks of exchanging and interacting molecules that transmit patterns of information between cells. Sustained stem cell graft-to-host communication leads to remarkable trophic effects on endogenous brain cells and beneficial modulatory actions on innate and adaptive immune responses in vivo, ultimately promoting the healing of the injured CNS. Among a number of adult stem cell types, mesenchymal stem cells (MSCs) and neural stem/precursor cells (NPCs) are being extensively investigated for their ability to signal to the immune system upon transplantation in experimental CNS diseases. Here, we focus on the main cellular signaling pathways that grafted MSCs and NPCs use to establish a therapeutically relevant cross talk with host immune cells, while examining the role of inflammation in regulating some of the bidirectionality of these communications. We propose that the identification of the players involved in stem cell signaling might contribute to the development of innovative, high clinical impact therapeutics for inflammatory CNS diseases." @default.
- W2152125093 created "2016-06-24" @default.
- W2152125093 creator A5001612039 @default.
- W2152125093 creator A5033930940 @default.
- W2152125093 date "2013-04-30" @default.
- W2152125093 modified "2023-10-16" @default.
- W2152125093 title "How stem cells speak with host immune cells in inflammatory brain diseases" @default.
- W2152125093 cites W1504471840 @default.
- W2152125093 cites W1530294984 @default.
- W2152125093 cites W1562003034 @default.
- W2152125093 cites W1571387405 @default.
- W2152125093 cites W1600560134 @default.
- W2152125093 cites W1648125567 @default.
- W2152125093 cites W1718946616 @default.
- W2152125093 cites W1762620449 @default.
- W2152125093 cites W1963765937 @default.
- W2152125093 cites W1965810526 @default.
- W2152125093 cites W1965942744 @default.
- W2152125093 cites W1966008305 @default.
- W2152125093 cites W1966841015 @default.
- W2152125093 cites W1967367827 @default.
- W2152125093 cites W1967948196 @default.
- W2152125093 cites W1968409866 @default.
- W2152125093 cites W1970090707 @default.
- W2152125093 cites W1970512911 @default.
- W2152125093 cites W1970600368 @default.
- W2152125093 cites W1970698497 @default.
- W2152125093 cites W1975085253 @default.
- W2152125093 cites W1975164266 @default.
- W2152125093 cites W1975309815 @default.
- W2152125093 cites W1977121422 @default.
- W2152125093 cites W1977692564 @default.
- W2152125093 cites W1977876646 @default.
- W2152125093 cites W1977934887 @default.
- W2152125093 cites W1979043688 @default.
- W2152125093 cites W1980441719 @default.
- W2152125093 cites W1982023994 @default.
- W2152125093 cites W1983936685 @default.
- W2152125093 cites W1984454948 @default.
- W2152125093 cites W1984844169 @default.
- W2152125093 cites W1985366897 @default.
- W2152125093 cites W1985429617 @default.
- W2152125093 cites W1986321004 @default.
- W2152125093 cites W1986628684 @default.
- W2152125093 cites W1987270591 @default.
- W2152125093 cites W1987899329 @default.
- W2152125093 cites W1987980051 @default.
- W2152125093 cites W1988178045 @default.
- W2152125093 cites W1989560466 @default.
- W2152125093 cites W1989632074 @default.
- W2152125093 cites W1989921112 @default.
- W2152125093 cites W1991849900 @default.
- W2152125093 cites W1991870596 @default.
- W2152125093 cites W1991889240 @default.
- W2152125093 cites W1991996112 @default.
- W2152125093 cites W1992315767 @default.
- W2152125093 cites W1992414522 @default.
- W2152125093 cites W1992546098 @default.
- W2152125093 cites W1993326869 @default.
- W2152125093 cites W1994229336 @default.
- W2152125093 cites W1995088083 @default.
- W2152125093 cites W1997082970 @default.
- W2152125093 cites W1997504990 @default.
- W2152125093 cites W1998538509 @default.
- W2152125093 cites W1999470271 @default.
- W2152125093 cites W1999783884 @default.
- W2152125093 cites W2003079057 @default.
- W2152125093 cites W2003441429 @default.
- W2152125093 cites W2004872316 @default.
- W2152125093 cites W2005911189 @default.
- W2152125093 cites W2006201768 @default.
- W2152125093 cites W2008055490 @default.
- W2152125093 cites W2009626854 @default.
- W2152125093 cites W2012245919 @default.
- W2152125093 cites W2015613327 @default.
- W2152125093 cites W2016472046 @default.
- W2152125093 cites W2016858358 @default.
- W2152125093 cites W2018685391 @default.
- W2152125093 cites W2019706860 @default.
- W2152125093 cites W2020682158 @default.
- W2152125093 cites W2021916724 @default.
- W2152125093 cites W2022267938 @default.
- W2152125093 cites W2022329534 @default.
- W2152125093 cites W2024221937 @default.
- W2152125093 cites W2024326908 @default.
- W2152125093 cites W2025274607 @default.
- W2152125093 cites W2025787566 @default.
- W2152125093 cites W2026171674 @default.
- W2152125093 cites W2028239901 @default.
- W2152125093 cites W2028543273 @default.
- W2152125093 cites W2028654716 @default.
- W2152125093 cites W2029097180 @default.
- W2152125093 cites W2029770820 @default.
- W2152125093 cites W2034279215 @default.
- W2152125093 cites W2035809865 @default.
- W2152125093 cites W2035976926 @default.
- W2152125093 cites W2036480458 @default.
- W2152125093 cites W2036874650 @default.