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• W2152132352 abstract "Prolongation of action potential duration (APD) and altered calcium (Ca2+) handling in ventricular myocytes are commonly observed in heart failure (HF). This study describes a mathematical model of human HF, using a modified version of the Grandi et al. formulation for human ventricular action potential, which includes the late Na+ current (I NaL ). A sensitivity analysis is performed to investigate how the reported variability in HF remodeling might modulate the main electrophysiological (EP) characteristics in HF. Our simulations reproduced experimental observations in failing myocytes and the APD 90 was increased in 24% in HF versus normal ones, diastolic [Ca2+] i was slightly increased, whereas peak systolic [Ca2+] i was reduced to 41% of its normal value. From the sensitivity analysis it could be extracted that APD is particularly sensitive to I NaL and I NaK . The most impactful parameters on Ca2+ handling are the SERCA function, I NaL , I NaK , I leak , I Ca, b and I NCX ." @default.
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• W2152132352 date "2011-09-01" @default.
• W2152132352 modified "2023-09-23" @default.
• W2152132352 title "Simulation study of the electrophysiological mechanisms for heart failure phenotype" @default.
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