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• W2152149181 abstract "Bioflavonoids, such as quercetin, have recently emerged as a new class of chemotherapeutic drugs for the treatment of various cancer types, but are marred by their low potency and poor selectivity. We report that a short application of low-frequency ultrasound selectively sensitises prostate and skin cancer cells against quercetin. Pretreatment of cells with ultrasound (20 kHz, 2 W cm−2, 60 s) selectively induced cytotoxicity in skin and prostate cancer cells, while having minimal effect on corresponding normal cell lines. About 90% of the viable skin cancer cell population was lost within 48 h after ultrasound-quercetin (50 μ M) treatment. Ultrasound reduced the LC50 of quercetin for skin cancer cells by almost 80-fold, while showing no effect on LC50 for nonmalignant skin cells." @default.
• W2152149181 created "2016-06-24" @default.
• W2152149181 creator A5008944816 @default.
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• W2152149181 date "2005-02-01" @default.
• W2152149181 modified "2023-10-10" @default.
• W2152149181 title "Induction of cancer-specific cytotoxicity towards human prostate and skin cells using quercetin and ultrasound" @default.
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• W2152149181 doi "https://doi.org/10.1038/sj.bjc.6602364" @default.
• W2152149181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2362095" @default.
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