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• W2152159632 startingPage "2792" @default.
• W2152159632 abstract "ABSTRACT Matrix (M) protein mutants of vesicular stomatitis virus (VSV) are promising oncolytic agents for cancer therapy. Previous research has implicated Fas and PKR in apoptosis induced by other viruses. Here, we show that dominant-negative mutants of Fas and PKR inhibit M protein mutant virus-induced apoptosis. Most previous research has focused on the adapter protein FADD as a necessary transducer of Fas-mediated apoptosis. However, the expression of dominant-negative FADD had little effect on the induction of apoptosis by M protein mutant VSV. Instead, virus-induced apoptosis was inhibited by the expression of a dominant-negative mutant of the adapter protein Daxx. These data indicate that Daxx is more important than FADD for apoptosis induced by M protein mutant VSV. These results show that PKR- and Fas-mediated signaling play important roles in cell death during M protein mutant VSV infection and that Daxx has novel functions in the host response to virus infection by mediating virus-induced apoptosis." @default.
• W2152159632 created "2016-06-24" @default.
• W2152159632 creator A5042758683 @default.
• W2152159632 creator A5048872911 @default.
• W2152159632 date "2007-03-15" @default.
• W2152159632 modified "2023-10-16" @default.
• W2152159632 title "Oncolytic Vesicular Stomatitis Virus Induces Apoptosis via Signaling through PKR, Fas, and Daxx" @default.
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• W2152159632 doi "https://doi.org/10.1128/jvi.01760-06" @default.
• W2152159632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1865982" @default.
• W2152159632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17192316" @default.
• W2152159632 hasPublicationYear "2007" @default.
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