Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152166430> ?p ?o ?g. }
- W2152166430 endingPage "242" @default.
- W2152166430 startingPage "232" @default.
- W2152166430 abstract "Glypican-3 (GPC3) protein expression was determined by immunohistochemical analysis from 29 normal livers, 80 cirrhotic livers sample taken near hepatocellular carcinoma (HCC), and 87 cirrhotic livers without HCC. The levels for miR-657 and HCC-related gene mRNAs were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Also, a published microarray dataset was used for gene set enrichment analysis (GSEA) to investigate the relationship between GPC3- and HCC-related gene signatures. Kaplan–Meier analysis was used to evaluate the relationship between GPC3 and HCC recurrence. GPC3 protein expression was not detected in any of the 29 (0%) normal livers, but was detected in 32 of 87 (37%) cirrhotic livers without HCC, and 51 of 80 (64%) cirrhotic liver samples taken near HCC sites (P < 0.001). The GPC3-positive rate in cirrhotic livers of viral origin was 68% (27/40), which was significantly higher than for non-viral cirrhotic livers (11%, 5/47) (P < 0.001). Also, GPC3 expression positively correlated with mRNA expression of HCC-related genes in the qRT-PCR and GSEA evaluations. Furthermore, HCC recurrence in cirrhotic liver samples taken near HCC sites was significantly higher in the GPC3-positive group than the GPC3-negative group (Log-rank P = 0.02, HR = 3.26; 95% CI = 1.20–10.29). This study demonstrated that highly expression of GPC3 could enrich HCC-related genes’ mRNA expression and positive associate with dysplasia in cirrhotic livers. Therefore, GPC3 may serve as a precancerous biomarker in cirrhotic livers." @default.
- W2152166430 created "2016-06-24" @default.
- W2152166430 creator A5000877114 @default.
- W2152166430 creator A5002591086 @default.
- W2152166430 creator A5009104622 @default.
- W2152166430 creator A5012082461 @default.
- W2152166430 creator A5012605130 @default.
- W2152166430 creator A5022765898 @default.
- W2152166430 creator A5045553246 @default.
- W2152166430 creator A5074743331 @default.
- W2152166430 creator A5081487015 @default.
- W2152166430 creator A5084717592 @default.
- W2152166430 date "2014-12-25" @default.
- W2152166430 modified "2023-10-04" @default.
- W2152166430 title "Expression of glypican 3 enriches hepatocellular carcinoma development-related genes and associates with carcinogenesis in cirrhotic livers" @default.
- W2152166430 cites W1972372966 @default.
- W2152166430 cites W1972559150 @default.
- W2152166430 cites W1974338429 @default.
- W2152166430 cites W1976801200 @default.
- W2152166430 cites W1977415499 @default.
- W2152166430 cites W1981420563 @default.
- W2152166430 cites W1982729651 @default.
- W2152166430 cites W1986826580 @default.
- W2152166430 cites W1992314595 @default.
- W2152166430 cites W1995916162 @default.
- W2152166430 cites W1999877835 @default.
- W2152166430 cites W2008649060 @default.
- W2152166430 cites W2009671859 @default.
- W2152166430 cites W2012899811 @default.
- W2152166430 cites W2029325109 @default.
- W2152166430 cites W2031044515 @default.
- W2152166430 cites W2031930309 @default.
- W2152166430 cites W2038047778 @default.
- W2152166430 cites W2041219501 @default.
- W2152166430 cites W2049388096 @default.
- W2152166430 cites W2050562077 @default.
- W2152166430 cites W2053736927 @default.
- W2152166430 cites W2057127002 @default.
- W2152166430 cites W2058388773 @default.
- W2152166430 cites W2058579700 @default.
- W2152166430 cites W2059890071 @default.
- W2152166430 cites W2065589690 @default.
- W2152166430 cites W2068207552 @default.
- W2152166430 cites W2079186794 @default.
- W2152166430 cites W2080485848 @default.
- W2152166430 cites W2082805907 @default.
- W2152166430 cites W2088185132 @default.
- W2152166430 cites W2089098881 @default.
- W2152166430 cites W2096866380 @default.
- W2152166430 cites W2097407064 @default.
- W2152166430 cites W2101270576 @default.
- W2152166430 cites W2106285087 @default.
- W2152166430 cites W2107411106 @default.
- W2152166430 cites W2113530405 @default.
- W2152166430 cites W2130410032 @default.
- W2152166430 cites W2132403777 @default.
- W2152166430 cites W2141921962 @default.
- W2152166430 cites W2154239359 @default.
- W2152166430 cites W2170369650 @default.
- W2152166430 cites W2253298865 @default.
- W2152166430 cites W2322310797 @default.
- W2152166430 cites W4210271223 @default.
- W2152166430 cites W4241399562 @default.
- W2152166430 cites W4241900369 @default.
- W2152166430 cites W4254498553 @default.
- W2152166430 cites W4297745080 @default.
- W2152166430 cites W4368205260 @default.
- W2152166430 doi "https://doi.org/10.1093/carcin/bgu245" @default.
- W2152166430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25542894" @default.
- W2152166430 hasPublicationYear "2014" @default.
- W2152166430 type Work @default.
- W2152166430 sameAs 2152166430 @default.
- W2152166430 citedByCount "24" @default.
- W2152166430 countsByYear W21521664302015 @default.
- W2152166430 countsByYear W21521664302016 @default.
- W2152166430 countsByYear W21521664302017 @default.
- W2152166430 countsByYear W21521664302018 @default.
- W2152166430 countsByYear W21521664302019 @default.
- W2152166430 countsByYear W21521664302020 @default.
- W2152166430 countsByYear W21521664302021 @default.
- W2152166430 countsByYear W21521664302023 @default.
- W2152166430 crossrefType "journal-article" @default.
- W2152166430 hasAuthorship W2152166430A5000877114 @default.
- W2152166430 hasAuthorship W2152166430A5002591086 @default.
- W2152166430 hasAuthorship W2152166430A5009104622 @default.
- W2152166430 hasAuthorship W2152166430A5012082461 @default.
- W2152166430 hasAuthorship W2152166430A5012605130 @default.
- W2152166430 hasAuthorship W2152166430A5022765898 @default.
- W2152166430 hasAuthorship W2152166430A5045553246 @default.
- W2152166430 hasAuthorship W2152166430A5074743331 @default.
- W2152166430 hasAuthorship W2152166430A5081487015 @default.
- W2152166430 hasAuthorship W2152166430A5084717592 @default.
- W2152166430 hasBestOaLocation W21521664301 @default.
- W2152166430 hasConcept C104317684 @default.
- W2152166430 hasConcept C121608353 @default.
- W2152166430 hasConcept C126322002 @default.
- W2152166430 hasConcept C142724271 @default.
- W2152166430 hasConcept C150194340 @default.