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• W2152177625 abstract "ABSTRACT Single-strain infections and coinfections are frequently used to assess roles of virulence factors in infected tissues. After oral inoculation of mice, Yersinia pseudotuberculosis yopE and yopH mutants colonize the intestines and Peyer's patches in single-strain infections but fail to persist in competition with wild-type Y. pseudotuberculosis , indicating that these two infection models provide different insights into the roles of Yops. To determine how wild-type Y. pseudotuberculosis hinders yop mutant survival, yop mutant colonization and host responses were investigated in several different infection models that isolated specific features of wild-type Y. pseudotuberculosis infection. Infection with wild-type Y. pseudotuberculosis caused significantly more inflammation than yop mutants. Results from coinfections of gamma interferon (IFN-γ) −/− mice revealed that IFN-γ-regulated defenses target these mutants, suggesting that YopE and YopH protect Y. pseudotuberculosis from these defenses in BALB/c mice. We developed an oral-intraperitoneal infection model to evaluate the effects of spleen and liver colonization by Y. pseudotuberculosis on yop mutants in the intestines. Spleen and liver infection increased inflammation and decreased yop mutant survival in the intestines, indicating that infection of these organs has consequences in intestinal tissues. Finally, competition infections with Y. pseudotuberculosis mutants with various abilities to induce inflammation demonstrated that survival of the yopE , but not the yopH , mutant was consistently decreased in inflamed tissues. In summary, infection with Y. pseudotuberculosis in intestinal and systemic sites induces intestinal inflammation, which decreases yop mutant survival. Thus, competition studies with wild-type yersiniae reveal critical roles of Yops in combating host responses to a normal virulent infection." @default.
• W2152177625 created "2016-06-24" @default.
• W2152177625 creator A5011242545 @default.
• W2152177625 creator A5029110240 @default.
• W2152177625 date "2006-03-01" @default.
• W2152177625 modified "2023-10-11" @default.
• W2152177625 title "The Proinflammatory Response Induced by Wild-Type<i>Yersinia pseudotuberculosis</i>Infection Inhibits Survival of<i>yop</i>Mutants in the Gastrointestinal Tract and Peyer's Patches" @default.
• W2152177625 cites W1230782337 @default.
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• W2152177625 cites W1586370436 @default.
• W2152177625 cites W1908152925 @default.
• W2152177625 cites W1919821846 @default.
• W2152177625 cites W1928333738 @default.
• W2152177625 cites W1966285973 @default.
• W2152177625 cites W1967472955 @default.
• W2152177625 cites W1971681859 @default.
• W2152177625 cites W1974405307 @default.
• W2152177625 cites W1976300852 @default.
• W2152177625 cites W1984225158 @default.
• W2152177625 cites W1989432109 @default.
• W2152177625 cites W1989745352 @default.
• W2152177625 cites W1991236622 @default.
• W2152177625 cites W1993244364 @default.
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• W2152177625 cites W2003253889 @default.
• W2152177625 cites W2009423065 @default.
• W2152177625 cites W2011696576 @default.
• W2152177625 cites W2013543532 @default.
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• W2152177625 cites W2021411873 @default.
• W2152177625 cites W2021710207 @default.
• W2152177625 cites W2024929819 @default.
• W2152177625 cites W2027509917 @default.
• W2152177625 cites W2047945304 @default.
• W2152177625 cites W2052875067 @default.
• W2152177625 cites W2085758279 @default.
• W2152177625 cites W2089262366 @default.
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• W2152177625 cites W2098259249 @default.
• W2152177625 cites W2101684624 @default.
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• W2152177625 cites W2134768631 @default.
• W2152177625 cites W2138401175 @default.
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• W2152177625 doi "https://doi.org/10.1128/iai.74.3.1516-1527.2006" @default.
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