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• W2152193803 abstract "Alveolar soft part sarcoma (ASPS) is a rare but highly malignant soft tissue tumor that affects mostly adolescents and young adults. To date, little molecular genetic information is available on this tumor of uncertain histogenesis. To expand our knowledge of this malignancy, we studied a recent case of ASPS by various molecular genetic techniques. Known chromosomal rearrangements associated with other pediatric solid tumors, including t(1;13)(p36;q14), t(2;13)(q35;q14), t(11;22)(q24;q12), and t(11;22)(p13;q12) were not detected by reverse transcriptase polymerase chain reaction (RT-PCR). The MYCN gene was not amplified, but a chromosome 1p deletion was evident by fluorescence in situ hybridization. By representational difference analysis, two amplified DNA sequences were identified. The first sequence showed no significant nucleic acid identity with known genes and was mapped to chromosomal region 19q12–13.1. The second sequence showed significant nucleic acid identity to the human beta-tryptase precurso..." @default.
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• W2152193803 date "1998-01-01" @default.
• W2152193803 modified "2023-09-22" @default.
• W2152193803 title "Molecular Genetic Changes in Alveolar Soft Part Sarcoma" @default.
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• W2152193803 doi "https://doi.org/10.1080/15513819809168805" @default.
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