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- W2152194808 abstract "® , a living human dermal replacement, as an adjunct therapy. The cost of conventional management of foot ulcers was established by surveying specialist clinics for typical resource use and applying published unit costs. A Markov model was used to estimate expected cost per ulcer healed, with and without Dermagraft, drawing on effectiveness data from the pivotal clinical trial. The expected use of Dermagraft in Australian specialist clinics was based on an observational case study of 27 hard to heal ulcers. The data from this study was also used to establish an alternative cost-effectiveness estimate, using a pre-post own control study design. Using the Markov model, the mean cost per ulcer healed is estimated at $10,906 using conventional management and $12,128 using Dermagraft as an adjunct or $9,393 if Dermagraft is cut and used to treat two ulcers. In the case studies, a mean 7.6 applications of Dermagraft were used per ulcer, with healing achieved in 85 per cent of ulcers. Based on the case studies, the mean cost of managing an ulcer after commencement with Dermagraft - until healing was achieved or to 24 weeks - was $4,682, compared with an estimated $12,500 incurred under conventional management prior to Dermagraft use. The use of Dermagraft as an adjunct to conventional management in the specialist clinic setting for hard to heal ulcers results in a similar average cost per ulcer healed and a lower cost per week in a healed state to conventional management alone. A shorter treatment period, fewer complications and fewer inpatient episodes will, in some cases, offset the cost of Dermagraft making the treatment cost saving." @default.
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- W2152194808 date "2002-05-01" @default.
- W2152194808 modified "2023-10-17" @default.
- W2152194808 title "The Use of Dermagraft in Neuropathic Foot Ulcers in People with Diabetes: An Economic Analysis for Australia" @default.
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