Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152195183> ?p ?o ?g. }
- W2152195183 endingPage "94" @default.
- W2152195183 startingPage "81" @default.
- W2152195183 abstract "A unified mathematical description that expresses the characteristics of whole systems is necessary for an understanding of signal transduction cascades. In this study we explore an algebraic method, named extreme signaling flow, enhanced from the concept of extreme pathway, to analyze signal transduction systems. This method enables us to represent the long-term potentiation (LTP) and the long-term depression (LTD) of hippocampal neuronal plasticity in an integrated simulation model. The model is validated by comparing the results of redundancy, reaction participation, and in silico knockout analysis with biological knowledge available from the literature. The following properties are assumed in these computational analyses: (1) LTP is fault-tolerant under network modification, (2) protein kinase C and MAPK have numerous routes to LTP induction, (3) calcium-calmodulin kinase II has a few routes to LTP induction, and (4) calcineurin has many routes to LTD induction. These results demonstrate that our approach produces an integrated framework for analyzing properties of large-scale systems with complicated signal transduction." @default.
- W2152195183 created "2016-06-24" @default.
- W2152195183 creator A5005428403 @default.
- W2152195183 creator A5015575713 @default.
- W2152195183 creator A5034496276 @default.
- W2152195183 creator A5043135854 @default.
- W2152195183 creator A5071767668 @default.
- W2152195183 date "2008-01-01" @default.
- W2152195183 modified "2023-09-27" @default.
- W2152195183 title "Algebraic Method for the Analysis of Signaling Crosstalk" @default.
- W2152195183 cites W1485679631 @default.
- W2152195183 cites W1557955256 @default.
- W2152195183 cites W1560716065 @default.
- W2152195183 cites W1965518203 @default.
- W2152195183 cites W1966392395 @default.
- W2152195183 cites W1967318257 @default.
- W2152195183 cites W1979955019 @default.
- W2152195183 cites W1980717706 @default.
- W2152195183 cites W1983682905 @default.
- W2152195183 cites W1983956991 @default.
- W2152195183 cites W1997907361 @default.
- W2152195183 cites W2002927748 @default.
- W2152195183 cites W2006113884 @default.
- W2152195183 cites W2008818443 @default.
- W2152195183 cites W2020869636 @default.
- W2152195183 cites W2025663053 @default.
- W2152195183 cites W2026089579 @default.
- W2152195183 cites W2030134162 @default.
- W2152195183 cites W2038262676 @default.
- W2152195183 cites W2041165019 @default.
- W2152195183 cites W2042295311 @default.
- W2152195183 cites W2047228180 @default.
- W2152195183 cites W2052322593 @default.
- W2152195183 cites W2054975255 @default.
- W2152195183 cites W2055350432 @default.
- W2152195183 cites W2063475537 @default.
- W2152195183 cites W2066580949 @default.
- W2152195183 cites W2080152563 @default.
- W2152195183 cites W2089083186 @default.
- W2152195183 cites W2093906292 @default.
- W2152195183 cites W2096652014 @default.
- W2152195183 cites W2098709515 @default.
- W2152195183 cites W2099039198 @default.
- W2152195183 cites W2101744311 @default.
- W2152195183 cites W2102256305 @default.
- W2152195183 cites W2106389606 @default.
- W2152195183 cites W2108590631 @default.
- W2152195183 cites W2109208582 @default.
- W2152195183 cites W2117486132 @default.
- W2152195183 cites W2128834282 @default.
- W2152195183 cites W2130790725 @default.
- W2152195183 cites W2133667940 @default.
- W2152195183 cites W2145600675 @default.
- W2152195183 cites W2156499867 @default.
- W2152195183 cites W2157239641 @default.
- W2152195183 cites W2162884728 @default.
- W2152195183 cites W2163480486 @default.
- W2152195183 cites W2163883777 @default.
- W2152195183 cites W4255087327 @default.
- W2152195183 cites W4366111279 @default.
- W2152195183 doi "https://doi.org/10.1162/artl.2008.14.1.81" @default.
- W2152195183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18171132" @default.
- W2152195183 hasPublicationYear "2008" @default.
- W2152195183 type Work @default.
- W2152195183 sameAs 2152195183 @default.
- W2152195183 citedByCount "2" @default.
- W2152195183 countsByYear W21521951832013 @default.
- W2152195183 crossrefType "journal-article" @default.
- W2152195183 hasAuthorship W2152195183A5005428403 @default.
- W2152195183 hasAuthorship W2152195183A5015575713 @default.
- W2152195183 hasAuthorship W2152195183A5034496276 @default.
- W2152195183 hasAuthorship W2152195183A5043135854 @default.
- W2152195183 hasAuthorship W2152195183A5071767668 @default.
- W2152195183 hasConcept C104317684 @default.
- W2152195183 hasConcept C111919701 @default.
- W2152195183 hasConcept C127413603 @default.
- W2152195183 hasConcept C152124472 @default.
- W2152195183 hasConcept C169760540 @default.
- W2152195183 hasConcept C169822122 @default.
- W2152195183 hasConcept C170493617 @default.
- W2152195183 hasConcept C186060115 @default.
- W2152195183 hasConcept C24326235 @default.
- W2152195183 hasConcept C25274449 @default.
- W2152195183 hasConcept C2775905019 @default.
- W2152195183 hasConcept C41008148 @default.
- W2152195183 hasConcept C55493867 @default.
- W2152195183 hasConcept C62478195 @default.
- W2152195183 hasConcept C70721500 @default.
- W2152195183 hasConcept C86803240 @default.
- W2152195183 hasConcept C95444343 @default.
- W2152195183 hasConceptScore W2152195183C104317684 @default.
- W2152195183 hasConceptScore W2152195183C111919701 @default.
- W2152195183 hasConceptScore W2152195183C127413603 @default.
- W2152195183 hasConceptScore W2152195183C152124472 @default.
- W2152195183 hasConceptScore W2152195183C169760540 @default.
- W2152195183 hasConceptScore W2152195183C169822122 @default.
- W2152195183 hasConceptScore W2152195183C170493617 @default.
- W2152195183 hasConceptScore W2152195183C186060115 @default.