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• W2152238239 startingPage "1065" @default.
• W2152238239 abstract "When proliferating fission yeast cells are exposed to nitrogen starvation, they initiate conjugation and differentiate into ascospores. Cell cycle arrest in the G 1 -phase is one of the prerequisites for cell differentiation, because conjugation occurs only in the pre-Start G 1 -phase. The role ofste9 + in the cell cycle progression was investigated. Ste9 is a WD-repeat protein that is highly homologous to Hct1/Cdh1 and Fizzy-related. The ste9 mutants were sterile because they were defective in cell cycle arrest in the G 1 -phase upon starvation. Sterility was partially suppressed by the mutation in cig2 that encoded the major G 1 /S cyclin. Although cells lacking Ste9 function grow normally, the ste9 mutation was synthetically lethal with the wee1 mutation. In the double mutants ofste9 cdc10 ts , cells arrested in G 1 -phase at the restrictive temperature, but the level of mitotic cyclin (Cdc13) did not decrease. In these cells, abortive mitosis occurred from the pre-Start G 1 -phase. Overexpression of Ste9 decreased the Cdc13 protein level and the H1-histone kinase activity. In these cells, mitosis was inhibited and an extra round of DNA replication occurred. Ste9 regulates G 1 progression possibly by controlling the amount of the mitotic cyclin in the G 1 -phase." @default.
• W2152238239 created "2016-06-24" @default.
• W2152238239 creator A5003424602 @default.
• W2152238239 creator A5006817475 @default.
• W2152238239 creator A5034021116 @default.
• W2152238239 date "1998-05-01" @default.
• W2152238239 modified "2023-09-23" @default.
• W2152238239 title "Fission Yeast Ste9, a Homolog of Hct1/Cdh1 and Fizzy-related, Is a Novel Negative Regulator of Cell Cycle Progression during G₁-Phase" @default.
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• W2152238239 doi "https://doi.org/10.1091/mbc.9.5.1065" @default.
• W2152238239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/25330" @default.
• W2152238239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9571240" @default.
• W2152238239 hasPublicationYear "1998" @default.
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