FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152248052> ?p ?o ?g. }

• W2152248052 abstract "Inhermaphroditic fish, the ovotestis can respond to external stimuli so that only one type of gonadal tissue (either ovarian or testicular tissue) will remain reproductively active and the other will recede to a rudimentary stage. However, the molecular mechanism for sexual fate determination is still poorly understood in hermaphroditic fish. In the present study, we examined whether sexual fate determination with respect to testis development is due to differential expression of dmrt1. Expression of dmrt1 was limited to the spermatogonia-surrounding cells (Sertoli cells) throughout testis development. Testicular dmrt1 was differentially expressed in fish (black porgy [Acanthopagrus schlegeliBleeker]) depending on if fish were destined to be female or male. Expression of dmrt1 in Sertoli cells did not require germ cell factors with busulfan treatment. To examine the role of dmrt1, we used virus-based RNA interference. Deficiency of dmrt1 resulted in a reduced number of germ cells in the testis and stimulated a male-to-female sex change. Higher serum luteinizing hormone levels were detected in 2+- to 3-yr-old male fish as compared to sex-changing female fish.Furthermore, we showed that fish treated in vivo with gonadotropin-releasing hormone (Gnrh) and fish treated in vitro with gonadotropin (Gth) had higher dmrt1 expression in the testis, suggesting that these endocrine factors may affect the male-to-female sex change. Therefore, our data suggest that dmrt1 plays a key role in initial testis differentiation and in later maintenance of male development. We show, to our knowledge for the first time, the functions of dmrt1 in hermaphroditic fish, which indicate that male-phase maintenance may be regulated by the brain-pituitary-gonadal axis via the Gnrh-Gth-Dmrt1 axis." @default.
• W2152248052 created "2016-06-24" @default.
• W2152248052 creator A5017598017 @default.
• W2152248052 creator A5037049573 @default.
• W2152248052 creator A5053385380 @default.
• W2152248052 creator A5067661200 @default.
• W2152248052 creator A5069807852 @default.
• W2152248052 creator A5071756225 @default.
• W2152248052 date "2012-02-01" @default.
• W2152248052 modified "2023-10-03" @default.
• W2152248052 title "Testicular dmrt1 Is Involved in the Sexual Fate of the Ovotestis in the Protandrous Black Porgy1" @default.
• W2152248052 cites W1615728431 @default.
• W2152248052 cites W1859775981 @default.
• W2152248052 cites W1964315134 @default.
• W2152248052 cites W1965762845 @default.
• W2152248052 cites W1968260974 @default.
• W2152248052 cites W1971056745 @default.
• W2152248052 cites W1971962787 @default.
• W2152248052 cites W1974397196 @default.
• W2152248052 cites W1976578360 @default.
• W2152248052 cites W1991279809 @default.
• W2152248052 cites W1991959445 @default.
• W2152248052 cites W1992091822 @default.
• W2152248052 cites W1993089672 @default.
• W2152248052 cites W1998795856 @default.
• W2152248052 cites W2001459984 @default.
• W2152248052 cites W2012858341 @default.
• W2152248052 cites W2015724653 @default.
• W2152248052 cites W2018170390 @default.
• W2152248052 cites W2022030472 @default.
• W2152248052 cites W2024806265 @default.
• W2152248052 cites W2030992877 @default.
• W2152248052 cites W2031541756 @default.
• W2152248052 cites W2035107915 @default.
• W2152248052 cites W2041784242 @default.
• W2152248052 cites W2050478791 @default.
• W2152248052 cites W2060637170 @default.
• W2152248052 cites W2068759614 @default.
• W2152248052 cites W2075458954 @default.
• W2152248052 cites W2077536806 @default.
• W2152248052 cites W2084222230 @default.
• W2152248052 cites W2084854441 @default.
• W2152248052 cites W2091123620 @default.
• W2152248052 cites W2092379587 @default.
• W2152248052 cites W2097050925 @default.
• W2152248052 cites W2098452577 @default.
• W2152248052 cites W2102190537 @default.
• W2152248052 cites W2107470969 @default.
• W2152248052 cites W2108445907 @default.
• W2152248052 cites W2109458831 @default.
• W2152248052 cites W2113265133 @default.
• W2152248052 cites W2116112998 @default.
• W2152248052 cites W2120682981 @default.
• W2152248052 cites W2123046711 @default.
• W2152248052 cites W2131111429 @default.
• W2152248052 cites W2148663279 @default.
• W2152248052 cites W2149492095 @default.
• W2152248052 cites W2154405295 @default.
• W2152248052 cites W2156497846 @default.
• W2152248052 cites W2158999293 @default.
• W2152248052 cites W2160084983 @default.
• W2152248052 cites W2165995004 @default.
• W2152248052 cites W4206900574 @default.
• W2152248052 doi "https://doi.org/10.1095/biolreprod.111.095695" @default.
• W2152248052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22034528" @default.
• W2152248052 hasPublicationYear "2012" @default.
• W2152248052 type Work @default.
• W2152248052 sameAs 2152248052 @default.
• W2152248052 citedByCount "64" @default.
• W2152248052 countsByYear W21522480522012 @default.
• W2152248052 countsByYear W21522480522013 @default.
• W2152248052 countsByYear W21522480522014 @default.
• W2152248052 countsByYear W21522480522015 @default.
• W2152248052 countsByYear W21522480522016 @default.
• W2152248052 countsByYear W21522480522017 @default.
• W2152248052 countsByYear W21522480522018 @default.
• W2152248052 countsByYear W21522480522019 @default.
• W2152248052 countsByYear W21522480522020 @default.
• W2152248052 countsByYear W21522480522021 @default.
• W2152248052 countsByYear W21522480522022 @default.
• W2152248052 countsByYear W21522480522023 @default.
• W2152248052 crossrefType "journal-article" @default.
• W2152248052 hasAuthorship W2152248052A5017598017 @default.
• W2152248052 hasAuthorship W2152248052A5037049573 @default.
• W2152248052 hasAuthorship W2152248052A5053385380 @default.
• W2152248052 hasAuthorship W2152248052A5067661200 @default.
• W2152248052 hasAuthorship W2152248052A5069807852 @default.
• W2152248052 hasAuthorship W2152248052A5071756225 @default.
• W2152248052 hasConcept C104317684 @default.
• W2152248052 hasConcept C123765429 @default.
• W2152248052 hasConcept C126322002 @default.
• W2152248052 hasConcept C134018914 @default.
• W2152248052 hasConcept C16685009 @default.
• W2152248052 hasConcept C2778620141 @default.
• W2152248052 hasConcept C2778782382 @default.
• W2152248052 hasConcept C2781068068 @default.
• W2152248052 hasConcept C2781471917 @default.
• W2152248052 hasConcept C54355233 @default.
• W2152248052 hasConcept C63405245 @default.
• W2152248052 hasConcept C71315377 @default.

• next