FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152252110> ?p ?o ?g. }

• W2152252110 endingPage "88" @default.
• W2152252110 startingPage "78" @default.
• W2152252110 abstract "Current understanding of the molecular mechanisms underlying mRNA degradation indicates that specific mRNA degradation rates are primarily encoded within the mRNA message itself in the form of cis-regulatory elements bearing particular primary sequences and/or secondary-structures. Such control elements are operated by RNA-binding proteins (RBPs) and/or miRNA-containing complexes. Based on the large number of RBPs and miRNAs encoded in metazoan genomes, their complex developmental expression and that specific RBP and miRNA interactions with mRNAs can lead to distinct degradation rates, I propose that developmental gene expression is shaped by a complex ‘mRNA degradation code’ with high information capacity. Localised cellular events involving the modification of RBP and/or miRNA target sequences in mRNAs by alternative polyadenylation added to the activation of specific RBP and miRNA activities via cell signalling are predicted to further expand the capacity of the mRNA degradation code by coupling it to dynamic events experienced by cells at specific spatiotemporal coordinates within the developing embryo. Current understanding of the molecular mechanisms underlying mRNA degradation indicates that specific mRNA degradation rates are primarily encoded within the mRNA message itself in the form of cis-regulatory elements bearing particular primary sequences and/or secondary-structures. Such control elements are operated by RNA-binding proteins (RBPs) and/or miRNA-containing complexes. Based on the large number of RBPs and miRNAs encoded in metazoan genomes, their complex developmental expression and that specific RBP and miRNA interactions with mRNAs can lead to distinct degradation rates, I propose that developmental gene expression is shaped by a complex ‘mRNA degradation code’ with high information capacity. Localised cellular events involving the modification of RBP and/or miRNA target sequences in mRNAs by alternative polyadenylation added to the activation of specific RBP and miRNA activities via cell signalling are predicted to further expand the capacity of the mRNA degradation code by coupling it to dynamic events experienced by cells at specific spatiotemporal coordinates within the developing embryo." @default.
• W2152252110 created "2016-06-24" @default.
• W2152252110 creator A5049021139 @default.
• W2152252110 date "2012-02-01" @default.
• W2152252110 modified "2023-09-26" @default.
• W2152252110 title "A complex ‘mRNA degradation code’ controls gene expression during animal development" @default.
• W2152252110 cites W144423133 @default.
• W2152252110 cites W1815472980 @default.
• W2152252110 cites W1864029557 @default.
• W2152252110 cites W1964727443 @default.
• W2152252110 cites W1965306643 @default.
• W2152252110 cites W1966985603 @default.
• W2152252110 cites W1968815795 @default.
• W2152252110 cites W1978961345 @default.
• W2152252110 cites W1982925662 @default.
• W2152252110 cites W1984574291 @default.
• W2152252110 cites W1988163167 @default.
• W2152252110 cites W1992935306 @default.
• W2152252110 cites W1992941735 @default.
• W2152252110 cites W1998929627 @default.
• W2152252110 cites W2000117107 @default.
• W2152252110 cites W2003911773 @default.
• W2152252110 cites W2004943023 @default.
• W2152252110 cites W2005558505 @default.
• W2152252110 cites W2010461414 @default.
• W2152252110 cites W2012403244 @default.
• W2152252110 cites W2012630877 @default.
• W2152252110 cites W2013782508 @default.
• W2152252110 cites W2015175027 @default.
• W2152252110 cites W2019824435 @default.
• W2152252110 cites W2020480100 @default.
• W2152252110 cites W2026644511 @default.
• W2152252110 cites W2028630156 @default.
• W2152252110 cites W2029706883 @default.
• W2152252110 cites W2031345354 @default.
• W2152252110 cites W2034500416 @default.
• W2152252110 cites W2037666638 @default.
• W2152252110 cites W2038179327 @default.
• W2152252110 cites W2039357236 @default.
• W2152252110 cites W2039684583 @default.
• W2152252110 cites W2044386270 @default.
• W2152252110 cites W2045365169 @default.
• W2152252110 cites W2046213721 @default.
• W2152252110 cites W2047479529 @default.
• W2152252110 cites W2048728930 @default.
• W2152252110 cites W2049127221 @default.
• W2152252110 cites W2049868101 @default.
• W2152252110 cites W2050433648 @default.
• W2152252110 cites W2053219805 @default.
• W2152252110 cites W2058059940 @default.
• W2152252110 cites W2059072211 @default.
• W2152252110 cites W2061795728 @default.
• W2152252110 cites W2065058688 @default.
• W2152252110 cites W2065566217 @default.
• W2152252110 cites W2066439289 @default.
• W2152252110 cites W2066793900 @default.
• W2152252110 cites W2067954811 @default.
• W2152252110 cites W2068778722 @default.
• W2152252110 cites W2076285440 @default.
• W2152252110 cites W2076627305 @default.
• W2152252110 cites W2080056404 @default.
• W2152252110 cites W2080532845 @default.
• W2152252110 cites W2088860412 @default.
• W2152252110 cites W2090009109 @default.
• W2152252110 cites W2093457298 @default.
• W2152252110 cites W2096378231 @default.
• W2152252110 cites W2097706279 @default.
• W2152252110 cites W2100555636 @default.
• W2152252110 cites W2106477243 @default.
• W2152252110 cites W2108284151 @default.
• W2152252110 cites W2121410013 @default.
• W2152252110 cites W2121624392 @default.
• W2152252110 cites W2123524671 @default.
• W2152252110 cites W2130801271 @default.
• W2152252110 cites W2135804883 @default.
• W2152252110 cites W2136400757 @default.
• W2152252110 cites W2138077148 @default.
• W2152252110 cites W2138664009 @default.
• W2152252110 cites W2139956963 @default.
• W2152252110 cites W2142571092 @default.
• W2152252110 cites W2145484948 @default.
• W2152252110 cites W2147997023 @default.
• W2152252110 cites W2149918332 @default.
• W2152252110 cites W2151562469 @default.
• W2152252110 cites W2151922790 @default.
• W2152252110 cites W2152083180 @default.
• W2152252110 cites W2152571861 @default.
• W2152252110 cites W2153401206 @default.
• W2152252110 cites W2157957964 @default.
• W2152252110 cites W2159376549 @default.
• W2152252110 cites W2160467221 @default.
• W2152252110 cites W2162674813 @default.
• W2152252110 cites W2163106706 @default.
• W2152252110 cites W2166430233 @default.
• W2152252110 cites W2167557255 @default.
• W2152252110 cites W2316662636 @default.
• W2152252110 cites W2334761118 @default.
• W2152252110 cites W4293081664 @default.

• next