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- W2152268660 abstract "After the initial observations by Kozek [1] and McLaren et al. [2] that filarial parasites are themselves host to endosymbiotic bacteria, nearly 20 years passed before the discovery that tetracycline and other drugs that target Wolbachia species interfere with worm molting and fertility [3]. This rediscovery led to an explosion of interest in the contribution of these bacteria to the pathogenesis of filarial disease, as well as interest in the potential utility of antibiotics for chemotherapy of filariasis [4]. Initial trials of doxycycline for the treatment of onchocerciasis and lymphatic filariasis (LF) have shown that 6-8-week courses of doxycycline treatment reduce levels of both microfilaria and Wolbachia species [5-8]. More important, there is evidence that adult worm fertility is com-" @default.
- W2152268660 created "2016-06-24" @default.
- W2152268660 creator A5071496730 @default.
- W2152268660 date "2006-04-15" @default.
- W2152268660 modified "2023-09-23" @default.
- W2152268660 title "The Promise of Wolbachia-Targeted Chemotherapy as a Public Health Intervention for Lymphatic Filariasis and Onchocerciasis" @default.
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- W2152268660 doi "https://doi.org/10.1086/501361" @default.
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