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• W2152275257 abstract "G proteins are molecular switches that control a wide variety of physiological functions, including neurotransmission, transcriptional activation, cell migration, cell growth. and proliferation. The ability of GTPases to participate in signaling events is determined by the ratio of GTP-bound to GDP-bound forms in the cell. All known GTPases exist in an inactive (GDP-bound) and an active (GTP-bound) conformation, which are catalyzed by guanine nucleotide exchange factors and GTPase-activating proteins (GAPs), respectively. In this study, we identified and characterized a new family of bifunctional GTP-binding and GTPase-activating proteins, named GGAP. GGAPs contain an N-terminal Ras homology domain, called the G domain, followed by a pleckstrin homology (PH) domain, a C-terminal GAP domain, and a tandem ankyrin (ANK) repeat domain. Expression analysis indicates that this new family of proteins has distinct cell localization, tissue distribution, and even message sizes. GTPase assays demonstrate that GGAPs have high GTPase activity through direct intramolecular interaction of the N-terminal G domain and the C-terminal GAP domain. In the absence of the GAP domain, the N-terminal G domain has very low activity, suggesting a new model of GGAP protein regulation via intramolecular interaction like the multidomain protein kinases. Overexpression of GGAPs leads to changes in cell morphology and activation of gene transcription." @default.
• W2152275257 created "2016-06-24" @default.
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• W2152275257 creator A5069078699 @default.
• W2152275257 creator A5080982128 @default.
• W2152275257 date "2003-04-01" @default.
• W2152275257 modified "2023-09-23" @default.
• W2152275257 title "GGAPs, a New Family of Bifunctional GTP-Binding and GTPase-Activating Proteins" @default.
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• W2152275257 doi "https://doi.org/10.1128/mcb.23.7.2476-2488.2003" @default.
• W2152275257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/150724" @default.
• W2152275257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12640130" @default.
• W2152275257 hasPublicationYear "2003" @default.
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