FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152276235> ?p ?o ?g. }

• W2152276235 endingPage "1371" @default.
• W2152276235 startingPage "1371" @default.
• W2152276235 abstract "Gray matter magnetic resonance imaging T2 hypointensity, a marker of iron deposition, is associated with clinical impairment and brain atrophy in cross-sectional studies of multiple sclerosis. Treatment with intramuscular interferon beta-1a limits brain atrophy in the second year of treatment.To test whether T2 hypointensity predicts brain atrophy and whether interferon affects this relationship.Post hoc analysis.A multicenter treatment trial conducted at tertiary care comprehensive multiple sclerosis centers. Patients Patients with multiple sclerosis who took part in a 2-year clinical trial in which they received intramuscular interferon beta-1a (30 mug/wk) or placebo.Deep gray matter T2 hypointensity, brain parenchymal fraction (BPF), and total T2, gadolinium-enhancing, and T1 lesion volumes.T2 hypointensity in various gray matter areas correlated with baseline BPF (r = 0.19-0.39; P = .001-.03). In placebo-treated patients (n = 68), baseline T2 hypointensity predicted the change in BPF in the first year and throughout 2 years (r = 0.26-0.42; P<.001-.03). T2 hypointensity was chosen in regression modeling as the best predictor of BPF change at the 1-year (R(2) = 0.23; P = .002) and 2-year (R(2) = 0.33; P<.001) time points after accounting for all magnetic resonance imaging variables. In the interferon group (n = 65), no relationship existed between baseline T2 hypointensity and BPF change.Gray matter T2 hypointensity predicts the progression of brain atrophy in placebo- but not interferon beta-1a-treated patients. This predictive effect is seen as early as the first year. We hypothesize that interferon beta may exert its effect on brain atrophy in part by reducing a cascade of events that involve iron deposition as a mediator of neurotoxicity or as a disease epiphenomenon." @default.
• W2152276235 created "2016-06-24" @default.
• W2152276235 creator A5002621424 @default.
• W2152276235 creator A5007615278 @default.
• W2152276235 creator A5009273315 @default.
• W2152276235 creator A5055764402 @default.
• W2152276235 creator A5066298482 @default.
• W2152276235 creator A5075596287 @default.
• W2152276235 creator A5083002276 @default.
• W2152276235 date "2005-09-01" @default.
• W2152276235 modified "2023-10-17" @default.
• W2152276235 title "Prediction of Longitudinal Brain Atrophy in Multiple Sclerosis by Gray Matter Magnetic Resonance Imaging T2 Hypointensity" @default.
• W2152276235 cites W1252868590 @default.
• W2152276235 cites W1902487112 @default.
• W2152276235 cites W1964385758 @default.
• W2152276235 cites W1978243650 @default.
• W2152276235 cites W1978340256 @default.
• W2152276235 cites W1984505558 @default.
• W2152276235 cites W1993296750 @default.
• W2152276235 cites W1993417921 @default.
• W2152276235 cites W1998299241 @default.
• W2152276235 cites W200099984 @default.
• W2152276235 cites W2001424726 @default.
• W2152276235 cites W2013948794 @default.
• W2152276235 cites W2017039912 @default.
• W2152276235 cites W2018275328 @default.
• W2152276235 cites W2021134630 @default.
• W2152276235 cites W2023385152 @default.
• W2152276235 cites W2023397563 @default.
• W2152276235 cites W2036909473 @default.
• W2152276235 cites W2044547913 @default.
• W2152276235 cites W2052065059 @default.
• W2152276235 cites W2059965956 @default.
• W2152276235 cites W2067276212 @default.
• W2152276235 cites W2069760926 @default.
• W2152276235 cites W2073729256 @default.
• W2152276235 cites W2075375643 @default.
• W2152276235 cites W2077031657 @default.
• W2152276235 cites W2079269640 @default.
• W2152276235 cites W2089793429 @default.
• W2152276235 cites W2100135031 @default.
• W2152276235 cites W2100650001 @default.
• W2152276235 cites W2104578899 @default.
• W2152276235 cites W2122871730 @default.
• W2152276235 cites W2123921524 @default.
• W2152276235 cites W2130355701 @default.
• W2152276235 cites W2132228594 @default.
• W2152276235 cites W2139367012 @default.
• W2152276235 cites W2144946000 @default.
• W2152276235 cites W2146057830 @default.
• W2152276235 cites W2147737565 @default.
• W2152276235 cites W2148726987 @default.
• W2152276235 cites W2152732392 @default.
• W2152276235 cites W2154447475 @default.
• W2152276235 cites W2156779938 @default.
• W2152276235 cites W2160870544 @default.
• W2152276235 cites W2164721910 @default.
• W2152276235 cites W2164863629 @default.
• W2152276235 cites W2168506602 @default.
• W2152276235 cites W2170387978 @default.
• W2152276235 cites W2325038063 @default.
• W2152276235 cites W2411274820 @default.
• W2152276235 doi "https://doi.org/10.1001/archneur.62.9.1371" @default.
• W2152276235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1435740" @default.
• W2152276235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16157744" @default.
• W2152276235 hasPublicationYear "2005" @default.
• W2152276235 type Work @default.
• W2152276235 sameAs 2152276235 @default.
• W2152276235 citedByCount "92" @default.
• W2152276235 countsByYear W21522762352012 @default.
• W2152276235 countsByYear W21522762352013 @default.
• W2152276235 countsByYear W21522762352014 @default.
• W2152276235 countsByYear W21522762352015 @default.
• W2152276235 countsByYear W21522762352016 @default.
• W2152276235 countsByYear W21522762352017 @default.
• W2152276235 countsByYear W21522762352018 @default.
• W2152276235 countsByYear W21522762352019 @default.
• W2152276235 countsByYear W21522762352020 @default.
• W2152276235 countsByYear W21522762352022 @default.
• W2152276235 crossrefType "journal-article" @default.
• W2152276235 hasAuthorship W2152276235A5002621424 @default.
• W2152276235 hasAuthorship W2152276235A5007615278 @default.
• W2152276235 hasAuthorship W2152276235A5009273315 @default.
• W2152276235 hasAuthorship W2152276235A5055764402 @default.
• W2152276235 hasAuthorship W2152276235A5066298482 @default.
• W2152276235 hasAuthorship W2152276235A5075596287 @default.
• W2152276235 hasAuthorship W2152276235A5083002276 @default.
• W2152276235 hasBestOaLocation W21522762351 @default.
• W2152276235 hasConcept C126322002 @default.
• W2152276235 hasConcept C126838900 @default.
• W2152276235 hasConcept C142724271 @default.
• W2152276235 hasConcept C143409427 @default.
• W2152276235 hasConcept C203014093 @default.
• W2152276235 hasConcept C204787440 @default.
• W2152276235 hasConcept C27081682 @default.
• W2152276235 hasConcept C2780640218 @default.
• W2152276235 hasConcept C2781172350 @default.
• W2152276235 hasConcept C2908698914 @default.

• next