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- W2152289076 endingPage "4459" @default.
- W2152289076 startingPage "4459" @default.
- W2152289076 abstract "L-Fucose-containing glycoconjugates are essential for a myriad of physiological and pathological activities, such as inflammation, bacterial and viral infections, tumor metastasis, and genetic disorders. Fucosyltransferases and fucosidases, the main enzymes involved in the incorporation and cleavage of L-fucose residues, respectively, represent captivating targets for therapeutic treatment and diagnosis. We herein review the important breakthroughs in the development of fucosyltransferase and fucosidase inhibitors. To demonstrate how the synthesized small molecules interact with the target enzymes, i.e. delineation of the structure-activity relationship, we cover the reaction mechanisms and resolved X-ray crystal structures, discuss how this information guides the design of enzyme inhibitors, and explain how the molecules were optimized to achieve satisfying potency and selectivity." @default.
- W2152289076 created "2016-06-24" @default.
- W2152289076 creator A5008951229 @default.
- W2152289076 creator A5026822350 @default.
- W2152289076 creator A5046615953 @default.
- W2152289076 date "2013-01-01" @default.
- W2152289076 modified "2023-10-17" @default.
- W2152289076 title "Development of fucosyltransferase and fucosidase inhibitors" @default.
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