FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152289968> ?p ?o ?g. }

• W2152289968 endingPage "61" @default.
• W2152289968 startingPage "51" @default.
• W2152289968 abstract "TRPM4 is a calcium-activated non-selective cation channel that is widely expressed and proposed to be involved in cell depolarization. In excitable cells, TRPM4 may regulate calcium influx by causing the depolarization that drives the activation of voltage-dependent calcium channels. We here report that insulin-secreting cells of the rat pancreatic beta-cell line INS-1 natively express TRPM4 proteins and generate large depolarizing membrane currents in response to increased intracellular calcium. These currents exhibit the characteristics of TRPM4 and can be suppressed by expressing a dominant negative TRPM4 construct, resulting in significantly decreased insulin secretion in response to a glucose stimulus. Reduced insulin secretion was also observed with arginine vasopressin stimulation, a Gq-coupled receptor agonist in beta-cells. Moreover, the recruitment of TRPM4 currents was biphasic in both INS-1 cells as well as HEK-293 cells overexpressing TRPM4. The first phase is due to activation of TRPM4 channels localized within the plasma membrane followed by a slower secondary phase, which is caused by the recruitment of TRPM4-containing vesicles to the plasma membrane during exocytosis. The secondary phase can be observed during perfusion of cells with increasing [Ca(2+)](i), replicated with agonist stimulation, and coincides with an increase in cell capacitance, loss of FM1-43 dye, and vesicle fusion. Our data suggest that TRPM4 may play a key role in the control of membrane potential and electrical activity of electrically excitable secretory cells and the dynamic translocation of TRPM4 from a vesicular pool to the plasma membrane via Ca(2+)-dependent exocytosis may represent a key short- and midterm regulatory mechanism by which cells regulate electrical activity." @default.
• W2152289968 created "2016-06-24" @default.
• W2152289968 creator A5024627397 @default.
• W2152289968 creator A5035340224 @default.
• W2152289968 creator A5040552985 @default.
• W2152289968 creator A5047064640 @default.
• W2152289968 creator A5058943509 @default.
• W2152289968 creator A5064410327 @default.
• W2152289968 creator A5066367346 @default.
• W2152289968 creator A5081265038 @default.
• W2152289968 date "2007-01-01" @default.
• W2152289968 modified "2023-10-05" @default.
• W2152289968 title "TRPM4 controls insulin secretion in pancreatic β-cells" @default.
• W2152289968 cites W1516382070 @default.
• W2152289968 cites W1531326750 @default.
• W2152289968 cites W1973764538 @default.
• W2152289968 cites W1975421593 @default.
• W2152289968 cites W1983615879 @default.
• W2152289968 cites W1983769291 @default.
• W2152289968 cites W1983992348 @default.
• W2152289968 cites W1994924615 @default.
• W2152289968 cites W1998269481 @default.
• W2152289968 cites W1999934349 @default.
• W2152289968 cites W2010986301 @default.
• W2152289968 cites W2017509811 @default.
• W2152289968 cites W2021815265 @default.
• W2152289968 cites W2024701933 @default.
• W2152289968 cites W2029785491 @default.
• W2152289968 cites W2032897738 @default.
• W2152289968 cites W2034791541 @default.
• W2152289968 cites W2036413106 @default.
• W2152289968 cites W2040664792 @default.
• W2152289968 cites W2047746821 @default.
• W2152289968 cites W2050076638 @default.
• W2152289968 cites W2052082800 @default.
• W2152289968 cites W2056716612 @default.
• W2152289968 cites W2066036961 @default.
• W2152289968 cites W2071358119 @default.
• W2152289968 cites W2089560759 @default.
• W2152289968 cites W2092925080 @default.
• W2152289968 cites W2095955574 @default.
• W2152289968 cites W2098512086 @default.
• W2152289968 cites W2101433657 @default.
• W2152289968 cites W2112043438 @default.
• W2152289968 cites W2112767644 @default.
• W2152289968 cites W2115963023 @default.
• W2152289968 cites W2116129077 @default.
• W2152289968 cites W2116643834 @default.
• W2152289968 cites W2117985191 @default.
• W2152289968 cites W2121570525 @default.
• W2152289968 cites W2123505183 @default.
• W2152289968 cites W2128167237 @default.
• W2152289968 cites W2132108132 @default.
• W2152289968 cites W2132675401 @default.
• W2152289968 cites W2135567029 @default.
• W2152289968 cites W2140188411 @default.
• W2152289968 cites W2151432329 @default.
• W2152289968 cites W2152984471 @default.
• W2152289968 cites W2164838292 @default.
• W2152289968 cites W2168142651 @default.
• W2152289968 cites W2258772639 @default.
• W2152289968 cites W2336304679 @default.
• W2152289968 doi "https://doi.org/10.1016/j.ceca.2006.04.032" @default.
• W2152289968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5663640" @default.
• W2152289968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16806463" @default.
• W2152289968 hasPublicationYear "2007" @default.
• W2152289968 type Work @default.
• W2152289968 sameAs 2152289968 @default.
• W2152289968 citedByCount "156" @default.
• W2152289968 countsByYear W21522899682012 @default.
• W2152289968 countsByYear W21522899682013 @default.
• W2152289968 countsByYear W21522899682014 @default.
• W2152289968 countsByYear W21522899682015 @default.
• W2152289968 countsByYear W21522899682016 @default.
• W2152289968 countsByYear W21522899682017 @default.
• W2152289968 countsByYear W21522899682018 @default.
• W2152289968 countsByYear W21522899682019 @default.
• W2152289968 countsByYear W21522899682020 @default.
• W2152289968 countsByYear W21522899682021 @default.
• W2152289968 countsByYear W21522899682022 @default.
• W2152289968 countsByYear W21522899682023 @default.
• W2152289968 crossrefType "journal-article" @default.
• W2152289968 hasAuthorship W2152289968A5024627397 @default.
• W2152289968 hasAuthorship W2152289968A5035340224 @default.
• W2152289968 hasAuthorship W2152289968A5040552985 @default.
• W2152289968 hasAuthorship W2152289968A5047064640 @default.
• W2152289968 hasAuthorship W2152289968A5058943509 @default.
• W2152289968 hasAuthorship W2152289968A5064410327 @default.
• W2152289968 hasAuthorship W2152289968A5066367346 @default.
• W2152289968 hasAuthorship W2152289968A5081265038 @default.
• W2152289968 hasBestOaLocation W21522899682 @default.
• W2152289968 hasConcept C12554922 @default.
• W2152289968 hasConcept C126322002 @default.
• W2152289968 hasConcept C134018914 @default.
• W2152289968 hasConcept C155164980 @default.
• W2152289968 hasConcept C170493617 @default.
• W2152289968 hasConcept C175969161 @default.
• W2152289968 hasConcept C178790620 @default.

• next