Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152293853> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2152293853 endingPage "3296" @default.
- W2152293853 startingPage "3284" @default.
- W2152293853 abstract "Developmental hip disorders (DHDs), eg, developmental dysplasia of the hip, slipped capitis femoris epiphysis, and femoroacetabular impingement, can be considered morphology variants of the normal hip. The femoroacetabular morphology of DHD is believed to induce osteoarthritis (OA) through local cumulative mechanical overload acting on genetically controlled patterning systems and subsequent damage of joint structures. However, it is unclear why hip morphology differs between individuals with seemingly comparable load histories and why certain hips with DHD progress to symptomatic OA whereas others do not.We asked (1) which mechanical factors influence growth and development of the proximal femur; and (2) which genes or genetic mechanisms are associated with hip ontogenesis.We performed a systematic literature review of mechanical and genetic factors of hip ontogeny. We focused on three fields that in recent years have advanced our knowledge of adult hip morphology: imaging, evolution, and genetics. WHERE ARE WE NOW?: Mechanical factors can be understood in view of human evolutionary peculiarities and may summate to load histories conducive to DHD. Genetic factors most likely act through multiple genes, each with modest effect sizes. Single genes that explain a DHD are therefore unlikely to be found. Apparently, the interplay between genes and load history not only determines hip morphotype, but also joint cartilage robustness (cartilotype) and resistance to symptomatic OA. WHERE DO WE NEED TO GO?: We need therapies that can improve both morphotype and cartilotype. HOW DO WE GET THERE?: Better phenotyping, improving classification systems of hip morphology, and comparative population studies can be done with existing methods. Quantifying load histories likely requires new tools, but proof of principle of modifying morphotype in treatment of DDH and of cartilotype with exercise is available." @default.
- W2152293853 created "2016-06-24" @default.
- W2152293853 creator A5006801083 @default.
- W2152293853 creator A5007897603 @default.
- W2152293853 creator A5008911804 @default.
- W2152293853 creator A5081123818 @default.
- W2152293853 date "2012-12-01" @default.
- W2152293853 modified "2023-10-02" @default.
- W2152293853 title "Hip Ontogenesis: How Evolution, Genes, and Load History Shape Hip Morphotype and Cartilotype" @default.
- W2152293853 cites W101669654 @default.
- W2152293853 cites W1660452224 @default.
- W2152293853 cites W1911826000 @default.
- W2152293853 cites W1967680722 @default.
- W2152293853 cites W2012618155 @default.
- W2152293853 cites W2043589375 @default.
- W2152293853 cites W2049973631 @default.
- W2152293853 cites W2131485509 @default.
- W2152293853 cites W2144157724 @default.
- W2152293853 cites W2151883188 @default.
- W2152293853 cites W2161998322 @default.
- W2152293853 cites W2287798861 @default.
- W2152293853 cites W2295509817 @default.
- W2152293853 cites W4242364918 @default.
- W2152293853 cites W4300810804 @default.
- W2152293853 cites W52859321 @default.
- W2152293853 doi "https://doi.org/10.1007/s11999-012-2511-4" @default.
- W2152293853 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3492609" @default.
- W2152293853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22926490" @default.
- W2152293853 hasPublicationYear "2012" @default.
- W2152293853 type Work @default.
- W2152293853 sameAs 2152293853 @default.
- W2152293853 citedByCount "39" @default.
- W2152293853 countsByYear W21522938532012 @default.
- W2152293853 countsByYear W21522938532013 @default.
- W2152293853 countsByYear W21522938532014 @default.
- W2152293853 countsByYear W21522938532015 @default.
- W2152293853 countsByYear W21522938532016 @default.
- W2152293853 countsByYear W21522938532017 @default.
- W2152293853 countsByYear W21522938532018 @default.
- W2152293853 countsByYear W21522938532019 @default.
- W2152293853 countsByYear W21522938532020 @default.
- W2152293853 countsByYear W21522938532021 @default.
- W2152293853 countsByYear W21522938532022 @default.
- W2152293853 crossrefType "journal-article" @default.
- W2152293853 hasAuthorship W2152293853A5006801083 @default.
- W2152293853 hasAuthorship W2152293853A5007897603 @default.
- W2152293853 hasAuthorship W2152293853A5008911804 @default.
- W2152293853 hasAuthorship W2152293853A5081123818 @default.
- W2152293853 hasBestOaLocation W21522938532 @default.
- W2152293853 hasConcept C105702510 @default.
- W2152293853 hasConcept C141071460 @default.
- W2152293853 hasConcept C142724271 @default.
- W2152293853 hasConcept C204787440 @default.
- W2152293853 hasConcept C2776164576 @default.
- W2152293853 hasConcept C2778842504 @default.
- W2152293853 hasConcept C2779961238 @default.
- W2152293853 hasConcept C2780472225 @default.
- W2152293853 hasConcept C2908647359 @default.
- W2152293853 hasConcept C71924100 @default.
- W2152293853 hasConcept C99454951 @default.
- W2152293853 hasConceptScore W2152293853C105702510 @default.
- W2152293853 hasConceptScore W2152293853C141071460 @default.
- W2152293853 hasConceptScore W2152293853C142724271 @default.
- W2152293853 hasConceptScore W2152293853C204787440 @default.
- W2152293853 hasConceptScore W2152293853C2776164576 @default.
- W2152293853 hasConceptScore W2152293853C2778842504 @default.
- W2152293853 hasConceptScore W2152293853C2779961238 @default.
- W2152293853 hasConceptScore W2152293853C2780472225 @default.
- W2152293853 hasConceptScore W2152293853C2908647359 @default.
- W2152293853 hasConceptScore W2152293853C71924100 @default.
- W2152293853 hasConceptScore W2152293853C99454951 @default.
- W2152293853 hasIssue "12" @default.
- W2152293853 hasLocation W21522938531 @default.
- W2152293853 hasLocation W21522938532 @default.
- W2152293853 hasLocation W21522938533 @default.
- W2152293853 hasLocation W21522938534 @default.
- W2152293853 hasOpenAccess W2152293853 @default.
- W2152293853 hasPrimaryLocation W21522938531 @default.
- W2152293853 hasRelatedWork W103967596 @default.
- W2152293853 hasRelatedWork W1977246851 @default.
- W2152293853 hasRelatedWork W1986692340 @default.
- W2152293853 hasRelatedWork W2079417862 @default.
- W2152293853 hasRelatedWork W2093037386 @default.
- W2152293853 hasRelatedWork W2252962373 @default.
- W2152293853 hasRelatedWork W2470162241 @default.
- W2152293853 hasRelatedWork W2474886114 @default.
- W2152293853 hasRelatedWork W2805365239 @default.
- W2152293853 hasRelatedWork W4220796176 @default.
- W2152293853 hasVolume "470" @default.
- W2152293853 isParatext "false" @default.
- W2152293853 isRetracted "false" @default.
- W2152293853 magId "2152293853" @default.
- W2152293853 workType "article" @default.