FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152315522> ?p ?o ?g. }

• W2152315522 endingPage "1206" @default.
• W2152315522 startingPage "1198" @default.
• W2152315522 abstract "Synaptoneurosomes obtained from the cortex of rat brain prelabeled with [14C] arachidonic acid ([14C]AA) were used as a source of substrate and enzyme in studies on the regulation of AA release. A significant amount of AA is liberated in the presence of 2 mM EGTA, independently of Ca2+, primarily from phosphatidic acid and polyphosphoinositides (poly-PI). Quinacrine, an inhibitor of phospholipase A2 (PLA2), suppressed AA release by about 60% and neomycin, a putative inhibitor of phospholipase C(PLC), reduced AA release by about 30%. An additive effect was exhibited when both inhibitors were given together. Ca2+ activated AA release. The level of Ca2+ present in the synaptoneurosomal preparation (endogenous level) and 5 μM CaC12 enhance AA liberation by approximately 25%, whereas 2 mM CaC12 resulted in a 50% increase in AA release relative to EGTA. The source for Ca2+-dependent AA release is predominantly phosphatidylinositol (PI); however, a small pool may also be liberated from neutral lipids. Carbachol, an agonist of the cholinergic receptor, stimulated Ca2+-dependent AA release by about 17%. Bradykinin enhanced the effect of carbachol by about 10–15%. This agonist-mediated AA release occurs specifically from phosphoinositides (PI + poly-PI). Quinacrine almost completely suppresses calcium- and carbachol-mediated AA release. Neomycin inhibits this process by about 30% and totally suppresses the effect of bradykinin. Our results indicate that both phospholipases PLA2 and PLC with subsequent action of DAG lipase are responsible for Ca2+- independent AA release. Ca2+-dependent and carbachol-mediated AA liberation occurs mainly as the result of PLA2action. A small pool of AA is probably also released by PLC, which seems to be exclusively responsible for the effect of bradykinin." @default.
• W2152315522 created "2016-06-24" @default.
• W2152315522 creator A5029245325 @default.
• W2152315522 creator A5063554480 @default.
• W2152315522 date "1991-10-01" @default.
• W2152315522 modified "2023-09-23" @default.
• W2152315522 title "Ca2+-Independent, Ca2+-Dependent, and Carbachol- Mediated Arachidonic Acid Release from Rat Brain Cortex Membrane" @default.
• W2152315522 cites W1480719130 @default.
• W2152315522 cites W1495950209 @default.
• W2152315522 cites W1527565099 @default.
• W2152315522 cites W1528829697 @default.
• W2152315522 cites W1579911888 @default.
• W2152315522 cites W1583075434 @default.
• W2152315522 cites W16075687 @default.
• W2152315522 cites W1751807524 @default.
• W2152315522 cites W178004509 @default.
• W2152315522 cites W1915481892 @default.
• W2152315522 cites W1967522314 @default.
• W2152315522 cites W1973691455 @default.
• W2152315522 cites W1975686097 @default.
• W2152315522 cites W1984787065 @default.
• W2152315522 cites W1988578707 @default.
• W2152315522 cites W1990294420 @default.
• W2152315522 cites W1994556559 @default.
• W2152315522 cites W2011083411 @default.
• W2152315522 cites W2015072125 @default.
• W2152315522 cites W2018773586 @default.
• W2152315522 cites W2030469059 @default.
• W2152315522 cites W2030854164 @default.
• W2152315522 cites W2034368055 @default.
• W2152315522 cites W2045035111 @default.
• W2152315522 cites W2052295727 @default.
• W2152315522 cites W2056402816 @default.
• W2152315522 cites W2065859210 @default.
• W2152315522 cites W2069062436 @default.
• W2152315522 cites W2079112334 @default.
• W2152315522 cites W2080258840 @default.
• W2152315522 cites W2088189616 @default.
• W2152315522 cites W2090732296 @default.
• W2152315522 cites W2116258055 @default.
• W2152315522 cites W2122903921 @default.
• W2152315522 cites W2152311269 @default.
• W2152315522 cites W2157018516 @default.
• W2152315522 cites W2326147096 @default.
• W2152315522 cites W2333221991 @default.
• W2152315522 cites W2333359926 @default.
• W2152315522 cites W2336559853 @default.
• W2152315522 cites W4252929497 @default.
• W2152315522 doi "https://doi.org/10.1111/j.1471-4159.1991.tb08280.x" @default.
• W2152315522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1910075" @default.
• W2152315522 hasPublicationYear "1991" @default.
• W2152315522 type Work @default.
• W2152315522 sameAs 2152315522 @default.
• W2152315522 citedByCount "32" @default.
• W2152315522 crossrefType "journal-article" @default.
• W2152315522 hasAuthorship W2152315522A5029245325 @default.
• W2152315522 hasAuthorship W2152315522A5063554480 @default.
• W2152315522 hasConcept C126322002 @default.
• W2152315522 hasConcept C134018914 @default.
• W2152315522 hasConcept C170493617 @default.
• W2152315522 hasConcept C178790620 @default.
• W2152315522 hasConcept C181199279 @default.
• W2152315522 hasConcept C185592680 @default.
• W2152315522 hasConcept C202751555 @default.
• W2152315522 hasConcept C2776551241 @default.
• W2152315522 hasConcept C2776711897 @default.
• W2152315522 hasConcept C2776909261 @default.
• W2152315522 hasConcept C2777658833 @default.
• W2152315522 hasConcept C2778078955 @default.
• W2152315522 hasConcept C2778597717 @default.
• W2152315522 hasConcept C2778918659 @default.
• W2152315522 hasConcept C2778938600 @default.
• W2152315522 hasConcept C2778988552 @default.
• W2152315522 hasConcept C2779591629 @default.
• W2152315522 hasConcept C2780610907 @default.
• W2152315522 hasConcept C41625074 @default.
• W2152315522 hasConcept C519063684 @default.
• W2152315522 hasConcept C55493867 @default.
• W2152315522 hasConcept C62478195 @default.
• W2152315522 hasConcept C71924100 @default.
• W2152315522 hasConcept C86803240 @default.
• W2152315522 hasConceptScore W2152315522C126322002 @default.
• W2152315522 hasConceptScore W2152315522C134018914 @default.
• W2152315522 hasConceptScore W2152315522C170493617 @default.
• W2152315522 hasConceptScore W2152315522C178790620 @default.
• W2152315522 hasConceptScore W2152315522C181199279 @default.
• W2152315522 hasConceptScore W2152315522C185592680 @default.
• W2152315522 hasConceptScore W2152315522C202751555 @default.
• W2152315522 hasConceptScore W2152315522C2776551241 @default.
• W2152315522 hasConceptScore W2152315522C2776711897 @default.
• W2152315522 hasConceptScore W2152315522C2776909261 @default.
• W2152315522 hasConceptScore W2152315522C2777658833 @default.
• W2152315522 hasConceptScore W2152315522C2778078955 @default.
• W2152315522 hasConceptScore W2152315522C2778597717 @default.
• W2152315522 hasConceptScore W2152315522C2778918659 @default.
• W2152315522 hasConceptScore W2152315522C2778938600 @default.
• W2152315522 hasConceptScore W2152315522C2778988552 @default.
• W2152315522 hasConceptScore W2152315522C2779591629 @default.

• next