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• W2152321828 abstract "SUBSTANCE P AND THE INNATE HOST RESPONSE by MEGAN ELIZABETH BLUHM FOLDENAUER May 2013 Advisor: Dr. Linda D. Hazlett Major: Anatomy and Cell Biology Degree: Doctor of Philosophy This body of work examined the mechanism by which SP regulates host immunity, specifically, its control of growth factors and TLR expression in the P. aeruginosa-infected cornea. The role of mTOR and VIP in corneal infection and inflammation also was tested. SP has a dual role in bacterial infection, unexpectedly upregulating growth factor production. This was accompanied by macrophage-specific upregulation of pro-inflammatory cytokines, downregulation of anti-inflammatory cytokines, and upregulation of anti-apoptotic genes, as well as a decrease in arginase-producing macrophages (M2 cells), important in stromal healing in these mice. All of these lead to worsened disease, despite the stimulatory effects on growth factor production and contraindicate clinical use of SP in cornea to promote wound healing, if an infection is present or suspected. Next, we provided evidence that IL-10 is regulated in the infected cornea via the mTOR pathway. This conclusion is based upon data showing that inhibition of mTOR by rapamycin decreased anti-inflammatory cytokines, particularly IL-10," @default.
• W2152321828 created "2016-06-24" @default.
• W2152321828 creator A5025566053 @default.
• W2152321828 date "2012-01-01" @default.
• W2152321828 modified "2023-09-27" @default.
• W2152321828 title "Substance P and the host immune response" @default.
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