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- W2152337733 abstract "Conflicts of interest: none declared. Sir, Bortezomib (Velcade®; Millennium Pharmaceuticals, Inc., Cambridge, MA, U.S.A.) is the first of a new class of antineoplastic agents, known as proteasome inhibitors, to be approved for the treatment of refractory multiple myeloma (MM). Recently, bortezomib has also shown promising single‐agent activity in patients with relapsed/refractory mantle cell lymphoma.1 We report the first ‘persistent supravenous eruption’ (PSE) induced by bortezomib. Cutaneous eruption is a relatively common toxicity seen in MM patients treated with bortezomib, and recently it has been well characterized.2, 3 Typically, skin lesions induced by bortezomib are characterized by an asymptomatic maculopapular or nodular rash located on the trunk and face that appears after at least two cycles, and recurs with more severity with subsequent cycles. It usually resolves with a combination of systemic corticosteroids and antihistamines, and to prevent recurrences, it is usually necessary to administer systemic corticosteroids before every infusion of bortezomib." @default.
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- W2152337733 date "2008-04-01" @default.
- W2152337733 modified "2023-09-27" @default.
- W2152337733 title "Persistent supravenous eruption induced by intravenous bortezomib therapy" @default.
- W2152337733 cites W1535082396 @default.
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- W2152337733 doi "https://doi.org/10.1111/j.1365-2133.2008.08438.x" @default.
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