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- W2152374185 abstract "Daduang et al. in this issue of Archives of Medical Science evaluate a disintegrin and metalloprotease (ADAM)12 level as a distinguishing biomarker between hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) [1]. Mean serum levels of ADAM12 in their study were higher in HCC compared with both CC and healthy controls (p < 0.001 for both combinations). Regarding specificity and positive likelihood ratio (PLR), ADAM12 had better specificity and PLR for HCC compared with CC (specificity: 77.4% vs. 64.5%, respectively; PLR: 3.51 vs. 1.25, respectively). Furthermore, serum levels of ADAM12 in HCC correlated with the overall survival (p = 0.02), indicating that high serum level of ADAM12 are associated with a significantly poorer prognosis. The conclusion reached was that ADAM12 may be used as an adjunct biomarker for the differential diagnosis between HCC and CC.Some additional comments may be of interest." @default.
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- W2152374185 date "2011-01-01" @default.
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- W2152374185 title "Editorials Predictors for the development of cholangiocarcinoma and hepatocellular carcinoma: in search for the most accurate biomarker" @default.
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- W2152374185 doi "https://doi.org/10.5114/aoms.2011.26600" @default.
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