Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152374411> ?p ?o ?g. }
- W2152374411 endingPage "208" @default.
- W2152374411 startingPage "189" @default.
- W2152374411 abstract "The aim of this review is to draw a correlation between the structure of the DNA/RNA hybrid and its properties as a substrate for the RNase H, as well as to point the crucial structural requirements for the modified AONs to preserve their RNase H potency. The review is divided into the following parts: (1) mechanistic considerations, (2) target RNA folding-AON folding-RNase H assistance in AON/RNA hybrid formation, (3) carbohydrate modifications, (4) backbone modifications, (5) base modifications, (6) conjugated AONs, (7) importance of the tethered chromophore in AON for the AON/RNA hybrid interactions with the RNase H. The structural changes in the AON/RNA hybrid duplexes brought by different modifications of the sugar, backbone or base in the antisense strand, and the effect of these changes on the RNase H recognition of the modified substrates have been addressed. Only those AON modifications and the corresponding AON/RNA hybrids, which have been structurally characterized by spectroscopic means and functionally analyzed by their ability to elicit RNase H potency in comparison with the native counterpart have been presented here." @default.
- W2152374411 created "2016-06-24" @default.
- W2152374411 creator A5000814916 @default.
- W2152374411 creator A5035166900 @default.
- W2152374411 creator A5068711541 @default.
- W2152374411 date "2001-05-01" @default.
- W2152374411 modified "2023-09-25" @default.
- W2152374411 title "A critical survey of the structure-function of the antisense oligo/RNA heteroduplex as substrate for RNase H" @default.
- W2152374411 cites W1551358827 @default.
- W2152374411 cites W1564730852 @default.
- W2152374411 cites W1845476218 @default.
- W2152374411 cites W1965536075 @default.
- W2152374411 cites W1967114346 @default.
- W2152374411 cites W1967705669 @default.
- W2152374411 cites W1972122374 @default.
- W2152374411 cites W1973822692 @default.
- W2152374411 cites W1975088062 @default.
- W2152374411 cites W1977991804 @default.
- W2152374411 cites W1979442620 @default.
- W2152374411 cites W1982010715 @default.
- W2152374411 cites W1983817073 @default.
- W2152374411 cites W1986481774 @default.
- W2152374411 cites W1988408638 @default.
- W2152374411 cites W1991112573 @default.
- W2152374411 cites W1992536933 @default.
- W2152374411 cites W1994777317 @default.
- W2152374411 cites W1996245771 @default.
- W2152374411 cites W1999935660 @default.
- W2152374411 cites W2001423847 @default.
- W2152374411 cites W2002552731 @default.
- W2152374411 cites W2002789953 @default.
- W2152374411 cites W2003598383 @default.
- W2152374411 cites W2003712894 @default.
- W2152374411 cites W2004925323 @default.
- W2152374411 cites W2006228317 @default.
- W2152374411 cites W2009207557 @default.
- W2152374411 cites W2010299178 @default.
- W2152374411 cites W2010566717 @default.
- W2152374411 cites W2018196842 @default.
- W2152374411 cites W2020476738 @default.
- W2152374411 cites W2020875914 @default.
- W2152374411 cites W2022285466 @default.
- W2152374411 cites W2025566170 @default.
- W2152374411 cites W2028094900 @default.
- W2152374411 cites W2028198542 @default.
- W2152374411 cites W2030799825 @default.
- W2152374411 cites W2031410480 @default.
- W2152374411 cites W2039389640 @default.
- W2152374411 cites W2040129193 @default.
- W2152374411 cites W2041527069 @default.
- W2152374411 cites W2044443446 @default.
- W2152374411 cites W2044595289 @default.
- W2152374411 cites W2045763555 @default.
- W2152374411 cites W2046218375 @default.
- W2152374411 cites W2046220821 @default.
- W2152374411 cites W2047282459 @default.
- W2152374411 cites W2047696159 @default.
- W2152374411 cites W2048091400 @default.
- W2152374411 cites W2048185836 @default.
- W2152374411 cites W2049094372 @default.
- W2152374411 cites W2050014764 @default.
- W2152374411 cites W2052294899 @default.
- W2152374411 cites W2053138556 @default.
- W2152374411 cites W2053999548 @default.
- W2152374411 cites W2054047850 @default.
- W2152374411 cites W2054281456 @default.
- W2152374411 cites W2057242202 @default.
- W2152374411 cites W2057622175 @default.
- W2152374411 cites W2057648499 @default.
- W2152374411 cites W2064059721 @default.
- W2152374411 cites W2067030279 @default.
- W2152374411 cites W2067728003 @default.
- W2152374411 cites W2068448175 @default.
- W2152374411 cites W2069883782 @default.
- W2152374411 cites W2075518667 @default.
- W2152374411 cites W2076293478 @default.
- W2152374411 cites W2080332253 @default.
- W2152374411 cites W2082998873 @default.
- W2152374411 cites W2090439353 @default.
- W2152374411 cites W2091559790 @default.
- W2152374411 cites W2093403421 @default.
- W2152374411 cites W2096739990 @default.
- W2152374411 cites W2101370516 @default.
- W2152374411 cites W2101619212 @default.
- W2152374411 cites W2108509653 @default.
- W2152374411 cites W2112529158 @default.
- W2152374411 cites W2112829828 @default.
- W2152374411 cites W2113911414 @default.
- W2152374411 cites W2117082238 @default.
- W2152374411 cites W2121954833 @default.
- W2152374411 cites W2129364859 @default.
- W2152374411 cites W2139562917 @default.
- W2152374411 cites W2149175059 @default.
- W2152374411 cites W2156169866 @default.
- W2152374411 cites W2162976476 @default.
- W2152374411 cites W2328348387 @default.
- W2152374411 cites W2953201325 @default.
- W2152374411 cites W4239370870 @default.