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- W2152394927 abstract "The major risks associated with coronary disease are angina, acute myocardial infarction, reduced cardiac function as manifest by depressed left ventricular ejection fraction and congestive heartfailure, and sudden arrhythmogenic cardiac death. During the past three decades, considerableadvances have been made in the management of patients with coronary heart disease with beta-blockers, calcium-channel blockers, angiotensin converting-enzyme (ACE) inhibitors, angiotensin receptor blockers, thrombolytics, balloon-stentangioplasty, and coronary artery bypass graftsurgery. The clinical course of patients with coronary disease has been meaningfully improved by these therapies, but sudden cardiac death remains a major problem and has not been impacted by these therapeutic interventions. Recently, the Center for Disease Control reported that more than 460 000 sudden cardiac deaths occur annually in the U.S., with sudden cardiac death accounting for 63% of all cardiac mortality events.1Following the introduction of the implanteddefibrillator in 1980, the defibrillator was initially utilized as secondary prevention for patients with aborted cardiac arrest or documented life-threatening ventricular tachycardia. In 1991, the Cardiac Arrhythmia Suppression Trial (CAST)investigators reported the ineffectiveness andactual harm associated with several promisingantiarrhythmic drugs that were being used toimprove survival in cardiac patients with manifest ventricular arrhythmias.2 That same year, ourMulticenter Automatic Defibrillator Implantation Trial (MADIT) research group initiated the firstrandomized trial to determine if an implantedcardioverter defibrillator (ICD) would save lives in coronary patients with prior myocardial infarction, reduced ejection fraction, non-sustained ventricular …" @default.
- W2152394927 created "2016-06-24" @default.
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- W2152394927 date "2003-01-01" @default.
- W2152394927 modified "2023-10-03" @default.
- W2152394927 title "MADIT-II and its implications" @default.
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- W2152394927 doi "https://doi.org/10.1016/s0195-668x(02)00627-9" @default.
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