FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152396721> ?p ?o ?g. }

• W2152396721 endingPage "17737" @default.
• W2152396721 startingPage "17732" @default.
• W2152396721 abstract "Recent advances suggest that it may be possible to construct simple artificial cells from two subsystems: a self-replicating cell membrane and a self-replicating genetic polymer. Although multiple pathways for the growth and division of model protocell membranes have been characterized, no self-replicating genetic material is yet available. Nonenzymatic template-directed synthesis of RNA with activated ribonucleotide monomers has led to the copying of short RNA templates; however, these reactions are generally slow (taking days to weeks) and highly error prone. N3'-P5'-linked phosphoramidate DNA (3'-NP-DNA) is similar to RNA in its overall duplex structure, and is attractive as an alternative to RNA because the high reactivity of its corresponding monomers allows rapid and efficient copying of all four nucleobases on homopolymeric RNA and DNA templates. Here we show that both homopolymeric and mixed-sequence 3'-NP-DNA templates can be copied into complementary 3'-NP-DNA sequences. G:T and A:C wobble pairing leads to a high error rate, but the modified nucleoside 2-thiothymidine suppresses wobble pairing. We show that the 2-thiothymidine modification increases both polymerization rate and fidelity in the copying of a 3'-NP-DNA template into a complementary strand of 3'-NP-DNA. Our results suggest that 3'-NP-DNA has the potential to serve as the genetic material of artificial biological systems." @default.
• W2152396721 created "2016-06-24" @default.
• W2152396721 creator A5011251007 @default.
• W2152396721 creator A5023274897 @default.
• W2152396721 creator A5039506372 @default.
• W2152396721 creator A5044291873 @default.
• W2152396721 creator A5050596026 @default.
• W2152396721 date "2013-10-07" @default.
• W2152396721 modified "2023-09-24" @default.
• W2152396721 title "Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer" @default.
• W2152396721 cites W1963989534 @default.
• W2152396721 cites W1973223999 @default.
• W2152396721 cites W1989130001 @default.
• W2152396721 cites W1989249011 @default.
• W2152396721 cites W1992304492 @default.
• W2152396721 cites W2010741413 @default.
• W2152396721 cites W2014425754 @default.
• W2152396721 cites W2026829672 @default.
• W2152396721 cites W2041313517 @default.
• W2152396721 cites W2042037994 @default.
• W2152396721 cites W2045643884 @default.
• W2152396721 cites W2048076644 @default.
• W2152396721 cites W2050478590 @default.
• W2152396721 cites W2050533681 @default.
• W2152396721 cites W2056152537 @default.
• W2152396721 cites W2057981403 @default.
• W2152396721 cites W2060537293 @default.
• W2152396721 cites W2066641965 @default.
• W2152396721 cites W2075445937 @default.
• W2152396721 cites W2089865129 @default.
• W2152396721 cites W2110977037 @default.
• W2152396721 cites W2113607740 @default.
• W2152396721 cites W2120012486 @default.
• W2152396721 cites W2123720645 @default.
• W2152396721 cites W2126901778 @default.
• W2152396721 cites W2145345565 @default.
• W2152396721 cites W2171421260 @default.
• W2152396721 cites W2824264007 @default.
• W2152396721 cites W2949353474 @default.
• W2152396721 cites W4238274068 @default.
• W2152396721 doi "https://doi.org/10.1073/pnas.1312329110" @default.
• W2152396721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3816440" @default.
• W2152396721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24101473" @default.
• W2152396721 hasPublicationYear "2013" @default.
• W2152396721 type Work @default.
• W2152396721 sameAs 2152396721 @default.
• W2152396721 citedByCount "64" @default.
• W2152396721 countsByYear W21523967212014 @default.
• W2152396721 countsByYear W21523967212015 @default.
• W2152396721 countsByYear W21523967212016 @default.
• W2152396721 countsByYear W21523967212017 @default.
• W2152396721 countsByYear W21523967212018 @default.
• W2152396721 countsByYear W21523967212019 @default.
• W2152396721 countsByYear W21523967212020 @default.
• W2152396721 countsByYear W21523967212021 @default.
• W2152396721 countsByYear W21523967212022 @default.
• W2152396721 crossrefType "journal-article" @default.
• W2152396721 hasAuthorship W2152396721A5011251007 @default.
• W2152396721 hasAuthorship W2152396721A5023274897 @default.
• W2152396721 hasAuthorship W2152396721A5039506372 @default.
• W2152396721 hasAuthorship W2152396721A5044291873 @default.
• W2152396721 hasAuthorship W2152396721A5050596026 @default.
• W2152396721 hasBestOaLocation W21523967211 @default.
• W2152396721 hasConcept C104317684 @default.
• W2152396721 hasConcept C114032466 @default.
• W2152396721 hasConcept C171250308 @default.
• W2152396721 hasConcept C192562407 @default.
• W2152396721 hasConcept C2776543447 @default.
• W2152396721 hasConcept C41625074 @default.
• W2152396721 hasConcept C512185932 @default.
• W2152396721 hasConcept C54355233 @default.
• W2152396721 hasConcept C552990157 @default.
• W2152396721 hasConcept C61234307 @default.
• W2152396721 hasConcept C67705224 @default.
• W2152396721 hasConcept C70721500 @default.
• W2152396721 hasConcept C82714645 @default.
• W2152396721 hasConcept C86803240 @default.
• W2152396721 hasConcept C98892162 @default.
• W2152396721 hasConceptScore W2152396721C104317684 @default.
• W2152396721 hasConceptScore W2152396721C114032466 @default.
• W2152396721 hasConceptScore W2152396721C171250308 @default.
• W2152396721 hasConceptScore W2152396721C192562407 @default.
• W2152396721 hasConceptScore W2152396721C2776543447 @default.
• W2152396721 hasConceptScore W2152396721C41625074 @default.
• W2152396721 hasConceptScore W2152396721C512185932 @default.
• W2152396721 hasConceptScore W2152396721C54355233 @default.
• W2152396721 hasConceptScore W2152396721C552990157 @default.
• W2152396721 hasConceptScore W2152396721C61234307 @default.
• W2152396721 hasConceptScore W2152396721C67705224 @default.
• W2152396721 hasConceptScore W2152396721C70721500 @default.
• W2152396721 hasConceptScore W2152396721C82714645 @default.
• W2152396721 hasConceptScore W2152396721C86803240 @default.
• W2152396721 hasConceptScore W2152396721C98892162 @default.
• W2152396721 hasIssue "44" @default.
• W2152396721 hasLocation W21523967211 @default.
• W2152396721 hasLocation W21523967212 @default.
• W2152396721 hasLocation W21523967213 @default.
• W2152396721 hasLocation W21523967214 @default.

• next