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• W2152401596 abstract "The cell cycle is the crucial process that leads to mitosis in all cell types. The dramatic redirectioning of many cellular processes during the cycle is known to involve ion channels, either changing their level of expression or their voltage dependence, as in the case of inward rectifiers. Here we describe the specific inhibition of heterologously expressed ionic channels at the onset of maturation in Xenopus oocytes. In cells expressing rat eag (R- eag ) potassium channels, maturation induces a dramatic reduction in the current amplitude, which is almost complete in most cases. The key molecule in oocyte maturation, the mitosis-promoting factor (a complex of cyclin B and p34 cdc2 ), is able to induce similar changes when injected into the oocytes." @default.
• W2152401596 created "2016-06-24" @default.
• W2152401596 creator A5000857311 @default.
• W2152401596 creator A5006282427 @default.
• W2152401596 creator A5069867327 @default.
• W2152401596 date "1997-01-21" @default.
• W2152401596 modified "2023-10-07" @default.
• W2152401596 title "Mitosis-promoting factor-mediated suppression of a cloned delayed rectifier potassium channel expressed in <i>Xenopus</i> oocytes" @default.
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• W2152401596 doi "https://doi.org/10.1073/pnas.94.2.537" @default.
• W2152401596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/19548" @default.
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• W2152401596 hasPublicationYear "1997" @default.
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