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• W2152450131 abstract "Arachidonic acid (AA) metabolites derived from both the lipoxygenase (LOX) and cyclooxygenase (COX) pathways transduce a variety of signals related to cell growth. Selective blockade of the different metabolic pathways of AA (using a general LOX inhibitor NDGA, a 5-LOX inhibitor AA861, a 12-LOX inhibitor baicalein and a general COX inhibitor ibuprofen) revealed that murine bladder cancer cell line (MBT-2) cell proliferation was inhibited by the LOX inhibitors concentration-dependently, but not by the COX inhibitor. Among the LOX inhibitors, baicalein showed the strongest inhibition and induced apoptosis of MBT-2. Proliferation of MBT-2 was also significantly inhibited by 12-LOX antisense oligonucleotides. In an in vivo experiment, the antitumor effects of baicalein administration on C3H/HeN mice implanted with MBT-2 were recognized. These results suggested that LOX inhibition may be significant in the treatment of bladder cancer." @default.
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• W2152450131 date "2004-05-27" @default.
• W2152450131 modified "2023-09-23" @default.
• W2152450131 title "Antitumor effects of lipoxygenase inhibitors on murine bladder cancer cell line (MBT-2)." @default.
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• W2152450131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15161019" @default.
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