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• W215245711 startingPage "1725" @default.
• W215245711 abstract "Abstract Members of the CCAAT/enhancer binding protein (C/EBP) family have been shown to regulate the terminal differentiation of adipocytes and hepatocytes. In these cell lineages, high levels of C/EBP alpha are found only in mature, nondividing cells. Using Western blotting and immunohistochemical staining, we have determined the temporal order of expression for C/EBP alpha, C/EBP beta, and C/EBP delta in differentiating myelomonocytic marrow cells. These studies show a unique temporal pattern of C/EBP isoform expression in the myeloid lineage. In particular, C/EBP alpha expression is very high in proliferative myelomonocytic cells, and diminishes during phenotypic maturation. While we have detected C/EBP alpha, C/EBP beta, and C/EBP delta in multiple myeloid leukemia cell lines, and C/EBP alpha in normal myeloid cells and in de novo human myeloid leukemias, we have not detected these C/EBP isoforms in either erythroid or lymphoid cells. Finally, we show that C/EBP alpha, C/EBP beta, and C/EBP delta protein and messenger RNA levels correlate in maturing granulocytic cells. The formation of tissue-specific combinations of C/EBP homodimers and heterodimers may allow this family of transcription factors to regulate different sets of genes in adipocytes, hepatocytes, and myelomonocytes." @default.
• W215245711 created "2016-06-24" @default.
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• W215245711 date "1992-10-01" @default.
• W215245711 modified "2023-10-16" @default.
• W215245711 title "A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells" @default.
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• W215245711 doi "https://doi.org/10.1182/blood.v80.7.1725.1725" @default.
• W215245711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1391942" @default.
• W215245711 hasPublicationYear "1992" @default.
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