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• W2152462912 abstract "We show that, contrary to expectations, restriction enzyme cleavage of chicken erythrocyte nucleosome core particle DNA generates a series of distinct subnucleosome fragments. These fragments do not result from bulk nucleosome phasing in vivo, but arise from micrococcal nuclease cleavages internal to the core particle, at roughly 10-base pair intervals and at AT-rich sequences. Those 145-base pair DNA fragments remaining intact are a biased population in which the guanine content can fluctuate by as much as 10%, with a 10-base pair period. We suggest that these same considerations, when applied to a unique DNA sequence, are the true explanation for several previous claims for nucleosome phasing." @default.
• W2152462912 created "2016-06-24" @default.
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• W2152462912 date "1983-04-01" @default.
• W2152462912 modified "2023-10-17" @default.
• W2152462912 title "Another potential artifact in the study of nucleosome phasing by chromatin digestion with micrococcal nuclease" @default.
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• W2152462912 doi "https://doi.org/10.1016/0092-8674(83)90303-3" @default.
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