FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152482321> ?p ?o ?g. }

• W2152482321 endingPage "322" @default.
• W2152482321 startingPage "311" @default.
• W2152482321 abstract "Summary High on-treatment platelet reactivity (HPR) has been identified as an independent risk factor for ischaemic events. The randomised, doubleblind, TRIPLET trial included a pre-defined comparison of HPR in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) following a placebo/600-mg clopidogrel loading dose (LD) immediately before a subsequent prasugrel 60-mg or 30-mg LD. Platelet reactivity was assessed using the VerifyNow® P2Y12 assay (P2Y12 Reaction Units, PRU) within 24 hours (h) following the placebo/clopidogrel LD (immediately prior to prasugrel LD), and at 2, 6, 24, 72 h following prasugrel LDs. The impact of CYP2C19 predicted metaboliser phenotype (extensive metaboliser [EM] and reduced metabolisers [RM]) on HPR status was also assessed. HPR (PRU ≥240) following the clopidogrel LD (prior to the prasugrel LD) was 58.5% in the combined clopidogrel LD groups. No significant difference was noted when stratified by time between the clopidogrel and prasugrel LDs (≤6 hs vs >6 h). At 6 h following the 2nd loading dose in the combined prasugrel LD groups, HPR was 7.1%, with 0% HPR by 72 h. There was no significant effect of CYP2C19 genotype on pharmacodynamic (PD) response following either prasugrel LD treatments at any time point, regardless of whether it was preceded by a clopidogrel 600-mg LD. In conclusion, in this study, patients with ACS intended for PCI showed a high prevalence of HPR after clopidogrel 600-mg LD regardless of metaboliser status. When prasugrel LD was added, HPR decreased substantially by 6 h, and was not seen by 72 h." @default.
• W2152482321 created "2016-06-24" @default.
• W2152482321 creator A5008442666 @default.
• W2152482321 creator A5018410713 @default.
• W2152482321 creator A5026616093 @default.
• W2152482321 creator A5033408468 @default.
• W2152482321 creator A5040418600 @default.
• W2152482321 creator A5046086774 @default.
• W2152482321 creator A5052292682 @default.
• W2152482321 creator A5061197322 @default.
• W2152482321 creator A5065463116 @default.
• W2152482321 creator A5070749831 @default.
• W2152482321 creator A5085434047 @default.
• W2152482321 creator A5088514884 @default.
• W2152482321 date "2014-01-01" @default.
• W2152482321 modified "2023-09-23" @default.
• W2152482321 title "Transferring from clopidogrel loading dose to prasugrel loading dose in acute coronary syndrome patients" @default.
• W2152482321 cites W144700851 @default.
• W2152482321 cites W1561075368 @default.
• W2152482321 cites W168371622 @default.
• W2152482321 cites W1978591428 @default.
• W2152482321 cites W1985059672 @default.
• W2152482321 cites W1985835171 @default.
• W2152482321 cites W1990018236 @default.
• W2152482321 cites W2001942881 @default.
• W2152482321 cites W2012343501 @default.
• W2152482321 cites W2016760364 @default.
• W2152482321 cites W2018234502 @default.
• W2152482321 cites W2020294937 @default.
• W2152482321 cites W2042758961 @default.
• W2152482321 cites W2044582644 @default.
• W2152482321 cites W2052397522 @default.
• W2152482321 cites W2056489784 @default.
• W2152482321 cites W2072544069 @default.
• W2152482321 cites W2081548185 @default.
• W2152482321 cites W2086278310 @default.
• W2152482321 cites W2092462003 @default.
• W2152482321 cites W2099022345 @default.
• W2152482321 cites W2108257482 @default.
• W2152482321 cites W2128228188 @default.
• W2152482321 cites W2140776066 @default.
• W2152482321 cites W2149441052 @default.
• W2152482321 cites W2152823642 @default.
• W2152482321 cites W2157833432 @default.
• W2152482321 cites W2159382450 @default.
• W2152482321 cites W2161785946 @default.
• W2152482321 cites W2170029016 @default.
• W2152482321 cites W2744105079 @default.
• W2152482321 cites W2968751749 @default.
• W2152482321 cites W3030817736 @default.
• W2152482321 cites W4205357827 @default.
• W2152482321 cites W4239335020 @default.
• W2152482321 doi "https://doi.org/10.1160/th13-09-0747" @default.
• W2152482321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24718367" @default.
• W2152482321 hasPublicationYear "2014" @default.
• W2152482321 type Work @default.
• W2152482321 sameAs 2152482321 @default.
• W2152482321 citedByCount "6" @default.
• W2152482321 countsByYear W21524823212014 @default.
• W2152482321 countsByYear W21524823212015 @default.
• W2152482321 countsByYear W21524823212019 @default.
• W2152482321 countsByYear W21524823212020 @default.
• W2152482321 crossrefType "journal-article" @default.
• W2152482321 hasAuthorship W2152482321A5008442666 @default.
• W2152482321 hasAuthorship W2152482321A5018410713 @default.
• W2152482321 hasAuthorship W2152482321A5026616093 @default.
• W2152482321 hasAuthorship W2152482321A5033408468 @default.
• W2152482321 hasAuthorship W2152482321A5040418600 @default.
• W2152482321 hasAuthorship W2152482321A5046086774 @default.
• W2152482321 hasAuthorship W2152482321A5052292682 @default.
• W2152482321 hasAuthorship W2152482321A5061197322 @default.
• W2152482321 hasAuthorship W2152482321A5065463116 @default.
• W2152482321 hasAuthorship W2152482321A5070749831 @default.
• W2152482321 hasAuthorship W2152482321A5085434047 @default.
• W2152482321 hasAuthorship W2152482321A5088514884 @default.
• W2152482321 hasConcept C126322002 @default.
• W2152482321 hasConcept C140840227 @default.
• W2152482321 hasConcept C2777028646 @default.
• W2152482321 hasConcept C2777628954 @default.
• W2152482321 hasConcept C2777698277 @default.
• W2152482321 hasConcept C2777849778 @default.
• W2152482321 hasConcept C2780400711 @default.
• W2152482321 hasConcept C27924281 @default.
• W2152482321 hasConcept C35294091 @default.
• W2152482321 hasConcept C42219234 @default.
• W2152482321 hasConcept C49059817 @default.
• W2152482321 hasConcept C500558357 @default.
• W2152482321 hasConcept C526171541 @default.
• W2152482321 hasConcept C62231903 @default.
• W2152482321 hasConcept C71924100 @default.
• W2152482321 hasConcept C98274493 @default.
• W2152482321 hasConceptScore W2152482321C126322002 @default.
• W2152482321 hasConceptScore W2152482321C140840227 @default.
• W2152482321 hasConceptScore W2152482321C2777028646 @default.
• W2152482321 hasConceptScore W2152482321C2777628954 @default.
• W2152482321 hasConceptScore W2152482321C2777698277 @default.
• W2152482321 hasConceptScore W2152482321C2777849778 @default.
• W2152482321 hasConceptScore W2152482321C2780400711 @default.

• next