FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152487777> ?p ?o ?g. }

• W2152487777 endingPage "608" @default.
• W2152487777 startingPage "600" @default.
• W2152487777 abstract "Polycystic liver disease (PLD) is a member of the cholangiopathies, a group of liver diseases in which cholangiocytes, the epithelia lining of the biliary tree, are the target cells. PLDs are caused by mutations in genes involved in intracellular signaling pathways, cell cycle regulation, and ciliogenesis, among others. We previously showed that cystic cholangiocytes have abnormal cell cycle profiles and malfunctioning cilia. Because histone deacetylase 6 (HDAC6) plays an important role in both cell cycle regulation and ciliary disassembly, we examined the role of HDAC6 in hepatic cystogenesis. HDAC6 protein was increased sixfold in cystic liver tissue and in cultured cholangiocytes isolated from both PCK rats (an animal model of PLD) and humans with PLD. Furthermore, pharmacological inhibition of HDAC6 by Tubastatin-A, Tubacin, and ACY-1215 decreased proliferation of cystic cholangiocytes in a dose- and time-dependent manner, and inhibited cyst growth in three-dimensional cultures. Importantly, ACY-1215 administered to PCK rats diminished liver cyst development and fibrosis. In summary, we show that HDAC6 is overexpressed in cystic cholangiocytes both in vitro and in vivo, and its pharmacological inhibition reduces cholangiocyte proliferation and cyst growth. These data suggest that HDAC6 may represent a potential novel therapeutic target for cases of PLD." @default.
• W2152487777 created "2016-06-24" @default.
• W2152487777 creator A5010082559 @default.
• W2152487777 creator A5014534094 @default.
• W2152487777 creator A5016284440 @default.
• W2152487777 creator A5062182791 @default.
• W2152487777 creator A5065588347 @default.
• W2152487777 creator A5072303032 @default.
• W2152487777 date "2014-03-01" @default.
• W2152487777 modified "2023-10-17" @default.
• W2152487777 title "HDAC6 Is Overexpressed in Cystic Cholangiocytes and Its Inhibition Reduces Cystogenesis" @default.
• W2152487777 cites W1518932181 @default.
• W2152487777 cites W1591944015 @default.
• W2152487777 cites W1828308889 @default.
• W2152487777 cites W1967539333 @default.
• W2152487777 cites W1992274728 @default.
• W2152487777 cites W1995864606 @default.
• W2152487777 cites W1997989369 @default.
• W2152487777 cites W1998419270 @default.
• W2152487777 cites W2000662468 @default.
• W2152487777 cites W2002561625 @default.
• W2152487777 cites W2005026678 @default.
• W2152487777 cites W2005938853 @default.
• W2152487777 cites W2008316305 @default.
• W2152487777 cites W2011924388 @default.
• W2152487777 cites W2015996357 @default.
• W2152487777 cites W2016268524 @default.
• W2152487777 cites W2018529989 @default.
• W2152487777 cites W2025128236 @default.
• W2152487777 cites W2029467007 @default.
• W2152487777 cites W2035638114 @default.
• W2152487777 cites W2048765726 @default.
• W2152487777 cites W2051550860 @default.
• W2152487777 cites W2057843157 @default.
• W2152487777 cites W2067983267 @default.
• W2152487777 cites W2073294365 @default.
• W2152487777 cites W2073637975 @default.
• W2152487777 cites W2081659168 @default.
• W2152487777 cites W2084343793 @default.
• W2152487777 cites W2085437068 @default.
• W2152487777 cites W2095026025 @default.
• W2152487777 cites W2098515013 @default.
• W2152487777 cites W2108017291 @default.
• W2152487777 cites W2114819889 @default.
• W2152487777 cites W2119503391 @default.
• W2152487777 cites W2128151020 @default.
• W2152487777 cites W2135830745 @default.
• W2152487777 cites W2136763924 @default.
• W2152487777 cites W2141470781 @default.
• W2152487777 cites W2146853374 @default.
• W2152487777 cites W2149555430 @default.
• W2152487777 cites W2151925930 @default.
• W2152487777 cites W2152653845 @default.
• W2152487777 cites W2153155610 @default.
• W2152487777 cites W2158358182 @default.
• W2152487777 cites W2162753434 @default.
• W2152487777 cites W2162787110 @default.
• W2152487777 cites W2167881829 @default.
• W2152487777 cites W2170411990 @default.
• W2152487777 doi "https://doi.org/10.1016/j.ajpath.2013.11.027" @default.
• W2152487777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3936326" @default.
• W2152487777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24434010" @default.
• W2152487777 hasPublicationYear "2014" @default.
• W2152487777 type Work @default.
• W2152487777 sameAs 2152487777 @default.
• W2152487777 citedByCount "40" @default.
• W2152487777 countsByYear W21524877772014 @default.
• W2152487777 countsByYear W21524877772015 @default.
• W2152487777 countsByYear W21524877772016 @default.
• W2152487777 countsByYear W21524877772017 @default.
• W2152487777 countsByYear W21524877772018 @default.
• W2152487777 countsByYear W21524877772019 @default.
• W2152487777 countsByYear W21524877772020 @default.
• W2152487777 countsByYear W21524877772021 @default.
• W2152487777 countsByYear W21524877772022 @default.
• W2152487777 countsByYear W21524877772023 @default.
• W2152487777 crossrefType "journal-article" @default.
• W2152487777 hasAuthorship W2152487777A5010082559 @default.
• W2152487777 hasAuthorship W2152487777A5014534094 @default.
• W2152487777 hasAuthorship W2152487777A5016284440 @default.
• W2152487777 hasAuthorship W2152487777A5062182791 @default.
• W2152487777 hasAuthorship W2152487777A5065588347 @default.
• W2152487777 hasAuthorship W2152487777A5072303032 @default.
• W2152487777 hasBestOaLocation W21524877771 @default.
• W2152487777 hasConcept C100094513 @default.
• W2152487777 hasConcept C104317684 @default.
• W2152487777 hasConcept C126322002 @default.
• W2152487777 hasConcept C134018914 @default.
• W2152487777 hasConcept C142724271 @default.
• W2152487777 hasConcept C1491633281 @default.
• W2152487777 hasConcept C195267511 @default.
• W2152487777 hasConcept C23681527 @default.
• W2152487777 hasConcept C2778305200 @default.
• W2152487777 hasConcept C2779609443 @default.
• W2152487777 hasConcept C2780021040 @default.
• W2152487777 hasConcept C2780186670 @default.
• W2152487777 hasConcept C2780597408 @default.
• W2152487777 hasConcept C2911091166 @default.

• next