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- W2152497434 abstract "Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in the mammalian genome and is essential for embryonic viability. With several of the key proteins now known, it has become possible to approach the biological significance of this epigenetic system through both biochemistry and genetics. As a result, advances have been made in our understanding of the mechanisms by which DNA methylation is targeted to specific regions of the genome and interpreted by methyl-CpG-binding proteins. Recent studies have illuminated the role of DNA methylation in controlling gene expression and have strengthened its links with histone modification and chromatin remodelling. Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in the mammalian genome and is essential for embryonic viability. With several of the key proteins now known, it has become possible to approach the biological significance of this epigenetic system through both biochemistry and genetics. As a result, advances have been made in our understanding of the mechanisms by which DNA methylation is targeted to specific regions of the genome and interpreted by methyl-CpG-binding proteins. Recent studies have illuminated the role of DNA methylation in controlling gene expression and have strengthened its links with histone modification and chromatin remodelling." @default.
- W2152497434 created "2016-06-24" @default.
- W2152497434 creator A5052906260 @default.
- W2152497434 creator A5073071237 @default.
- W2152497434 date "2006-02-01" @default.
- W2152497434 modified "2023-10-18" @default.
- W2152497434 title "Genomic DNA methylation: the mark and its mediators" @default.
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- W2152497434 doi "https://doi.org/10.1016/j.tibs.2005.12.008" @default.
- W2152497434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16403636" @default.