FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152498364> ?p ?o ?g. }

• W2152498364 endingPage "2817" @default.
• W2152498364 startingPage "2813" @default.
• W2152498364 abstract "Abstract In resting T cells, Csk is constitutively localized in lipid rafts by virtue of interaction with a phosphorylated adaptor protein, Csk-binding protein (Cbp)/phosphoprotein associated with glycolipid-enriched microdomains, and sets an activation threshold in TCR signaling. In this study, we examined a kinase responsible for Cbp phosphorylation in T cell membrane rafts. By analyzing T cells from Fyn−/− mice, we clearly demonstrated that Fyn, but not Lck, has its kinase activity in membrane rafts, and plays a critical role in Cbp phosphorylation, Cbp-Csk interaction, and Csk kinase activity. Naive CD44lowCD62 ligandhigh T cells were substantially reduced in Fyn−/− mice, presumably due to the inhibition of Cbp phosphorylation. Thus, Fyn mediates Cbp-Csk interaction and recruits Csk to rafts by phosphorylating Cbp. Csk recruited to rafts would then be activated and inhibit the kinase activity of Lck to keep resting T cells in a quiescent state. Our results elucidate a negative regulatory role for Fyn in proximal TCR signaling in lipid rafts." @default.
• W2152498364 created "2016-06-24" @default.
• W2152498364 creator A5008219921 @default.
• W2152498364 creator A5016768252 @default.
• W2152498364 creator A5034545696 @default.
• W2152498364 creator A5042837796 @default.
• W2152498364 creator A5049970977 @default.
• W2152498364 creator A5053568339 @default.
• W2152498364 creator A5064980375 @default.
• W2152498364 creator A5067009952 @default.
• W2152498364 creator A5076624164 @default.
• W2152498364 creator A5077255722 @default.
• W2152498364 creator A5077422183 @default.
• W2152498364 date "2002-09-15" @default.
• W2152498364 modified "2023-09-26" @default.
• W2152498364 title "Cutting Edge: Fyn Is Essential for Tyrosine Phosphorylation of Csk-Binding Protein/Phosphoprotein Associated with Glycolipid-Enriched Microdomains in Lipid Rafts in Resting T Cells" @default.
• W2152498364 cites W1548078808 @default.
• W2152498364 cites W1553517909 @default.
• W2152498364 cites W1564861448 @default.
• W2152498364 cites W1631329616 @default.
• W2152498364 cites W1974561108 @default.
• W2152498364 cites W1981660923 @default.
• W2152498364 cites W1994560135 @default.
• W2152498364 cites W1994806298 @default.
• W2152498364 cites W1996162251 @default.
• W2152498364 cites W2025170327 @default.
• W2152498364 cites W2025823475 @default.
• W2152498364 cites W2038424162 @default.
• W2152498364 cites W2064812124 @default.
• W2152498364 cites W2070166919 @default.
• W2152498364 cites W2099593237 @default.
• W2152498364 cites W2110464252 @default.
• W2152498364 cites W2121870374 @default.
• W2152498364 cites W2149764521 @default.
• W2152498364 cites W2160675888 @default.
• W2152498364 doi "https://doi.org/10.4049/jimmunol.169.6.2813" @default.
• W2152498364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12218089" @default.
• W2152498364 hasPublicationYear "2002" @default.
• W2152498364 type Work @default.
• W2152498364 sameAs 2152498364 @default.
• W2152498364 citedByCount "119" @default.
• W2152498364 countsByYear W21524983642012 @default.
• W2152498364 countsByYear W21524983642013 @default.
• W2152498364 countsByYear W21524983642014 @default.
• W2152498364 countsByYear W21524983642015 @default.
• W2152498364 countsByYear W21524983642017 @default.
• W2152498364 countsByYear W21524983642018 @default.
• W2152498364 countsByYear W21524983642019 @default.
• W2152498364 countsByYear W21524983642020 @default.
• W2152498364 countsByYear W21524983642021 @default.
• W2152498364 countsByYear W21524983642022 @default.
• W2152498364 countsByYear W21524983642023 @default.
• W2152498364 crossrefType "journal-article" @default.
• W2152498364 hasAuthorship W2152498364A5008219921 @default.
• W2152498364 hasAuthorship W2152498364A5016768252 @default.
• W2152498364 hasAuthorship W2152498364A5034545696 @default.
• W2152498364 hasAuthorship W2152498364A5042837796 @default.
• W2152498364 hasAuthorship W2152498364A5049970977 @default.
• W2152498364 hasAuthorship W2152498364A5053568339 @default.
• W2152498364 hasAuthorship W2152498364A5064980375 @default.
• W2152498364 hasAuthorship W2152498364A5067009952 @default.
• W2152498364 hasAuthorship W2152498364A5076624164 @default.
• W2152498364 hasAuthorship W2152498364A5077255722 @default.
• W2152498364 hasAuthorship W2152498364A5077422183 @default.
• W2152498364 hasBestOaLocation W21524983641 @default.
• W2152498364 hasConcept C108636557 @default.
• W2152498364 hasConcept C11960822 @default.
• W2152498364 hasConcept C183141693 @default.
• W2152498364 hasConcept C184235292 @default.
• W2152498364 hasConcept C185592680 @default.
• W2152498364 hasConcept C19317047 @default.
• W2152498364 hasConcept C196347352 @default.
• W2152498364 hasConcept C203014093 @default.
• W2152498364 hasConcept C2776090121 @default.
• W2152498364 hasConcept C2777061661 @default.
• W2152498364 hasConcept C2777553839 @default.
• W2152498364 hasConcept C2779976819 @default.
• W2152498364 hasConcept C37686147 @default.
• W2152498364 hasConcept C42362537 @default.
• W2152498364 hasConcept C62478195 @default.
• W2152498364 hasConcept C79266657 @default.
• W2152498364 hasConcept C86803240 @default.
• W2152498364 hasConcept C8891405 @default.
• W2152498364 hasConcept C95444343 @default.
• W2152498364 hasConceptScore W2152498364C108636557 @default.
• W2152498364 hasConceptScore W2152498364C11960822 @default.
• W2152498364 hasConceptScore W2152498364C183141693 @default.
• W2152498364 hasConceptScore W2152498364C184235292 @default.
• W2152498364 hasConceptScore W2152498364C185592680 @default.
• W2152498364 hasConceptScore W2152498364C19317047 @default.
• W2152498364 hasConceptScore W2152498364C196347352 @default.
• W2152498364 hasConceptScore W2152498364C203014093 @default.
• W2152498364 hasConceptScore W2152498364C2776090121 @default.
• W2152498364 hasConceptScore W2152498364C2777061661 @default.
• W2152498364 hasConceptScore W2152498364C2777553839 @default.
• W2152498364 hasConceptScore W2152498364C2779976819 @default.
• W2152498364 hasConceptScore W2152498364C37686147 @default.
• W2152498364 hasConceptScore W2152498364C42362537 @default.

• next