FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152510114> ?p ?o ?g. }

• W2152510114 endingPage "474" @default.
• W2152510114 startingPage "461" @default.
• W2152510114 abstract "The diagnosis of splenic marginal zone lymphoma (SMZL) is frequently a challenge, due to its lack of specific histological features and immunophenotypic markers, and the existence of other poorly characterized splenic lymphomas defying classification. Moreover, the clinical outcome of SMZL is variable, with 30% of cases pursuing an aggressive clinical course, the prediction of which remains problematic. Thus, there is a real need for biomarkers in the diagnosis and prognostication of SMZL. To search for genetic markers, we comprehensively investigated the genomic profile, TP53 abnormalities, and immunoglobulin heavy gene (IGH) mutation in a large cohort of SMZLs. 1 Mb resolution array comparative genomic hybridization (aCGH) on 25 SMZLs identified 7q32 deletion (44%) as the most frequent copy number change, followed by gains of 3q (32%), 8q (20%), 9q34 (20%), 12q23-24 (8%), and chromosome 18 (12%), and losses of 6q (16%), 8p (12%), and 17p (8%). High-resolution chromosome 7 tile-path aCGH on 17 SMZLs with 7q32 deletion identified by 1 Mb aCGH or interphase FISH screening mapped the minimal common deletion to a 3 Mb region at 7q32.1-32.2. Although it is not yet possible to identify the genes targeted by the deletion, interphase FISH screening showed that the deletion was seen in SMZL (19/56 = 34%) and splenic B-cell lymphoma/leukaemia unclassifiable (3/9 = 33%), but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia (n = 14), hairy cell leukaemia (4), mantle cell lymphoma (12), follicular lymphoma (6), and others. In SMZL, 7q32 deletion was inversely correlated with trisomy 18, but not associated with other copy number changes, TP53 abnormalities, or IGH mutation status. None of the genetic parameters examined showed significant and independent association with overall or event-free survival. In conclusion, 7q32 deletion is a characteristic feature of SMZL, albeit seen in isolated cases of splenic B-cell lymphoma/leukaemia unclassifiable, and its detection may help the differential diagnosis of splenic B-cell lymphomas." @default.
• W2152510114 created "2016-06-24" @default.
• W2152510114 creator A5004200273 @default.
• W2152510114 creator A5013059066 @default.
• W2152510114 creator A5020421276 @default.
• W2152510114 creator A5023312754 @default.
• W2152510114 creator A5031600864 @default.
• W2152510114 creator A5041110787 @default.
• W2152510114 creator A5046629044 @default.
• W2152510114 creator A5047554635 @default.
• W2152510114 creator A5051974926 @default.
• W2152510114 creator A5067656482 @default.
• W2152510114 creator A5079147077 @default.
• W2152510114 creator A5081418059 @default.
• W2152510114 creator A5082655055 @default.
• W2152510114 creator A5084191548 @default.
• W2152510114 creator A5084576706 @default.
• W2152510114 date "2009-11-30" @default.
• W2152510114 modified "2023-10-02" @default.
• W2152510114 title "Splenic marginal zone lymphoma: characterization of 7q deletion and its value in diagnosis" @default.
• W2152510114 cites W138963765 @default.
• W2152510114 cites W1544793881 @default.
• W2152510114 cites W1723358241 @default.
• W2152510114 cites W1967861083 @default.
• W2152510114 cites W1982365706 @default.
• W2152510114 cites W1988278234 @default.
• W2152510114 cites W1988389349 @default.
• W2152510114 cites W1990689171 @default.
• W2152510114 cites W1994763276 @default.
• W2152510114 cites W1994969140 @default.
• W2152510114 cites W2000812438 @default.
• W2152510114 cites W2006265632 @default.
• W2152510114 cites W2010421692 @default.
• W2152510114 cites W2014703763 @default.
• W2152510114 cites W2018324174 @default.
• W2152510114 cites W2018365232 @default.
• W2152510114 cites W2020094108 @default.
• W2152510114 cites W2023376095 @default.
• W2152510114 cites W2023767070 @default.
• W2152510114 cites W2027295659 @default.
• W2152510114 cites W2031737309 @default.
• W2152510114 cites W2033212459 @default.
• W2152510114 cites W2040706148 @default.
• W2152510114 cites W2045970616 @default.
• W2152510114 cites W2047267789 @default.
• W2152510114 cites W2054230441 @default.
• W2152510114 cites W2055573606 @default.
• W2152510114 cites W2059277626 @default.
• W2152510114 cites W2064519910 @default.
• W2152510114 cites W2068801231 @default.
• W2152510114 cites W2069386297 @default.
• W2152510114 cites W2070715981 @default.
• W2152510114 cites W2075164767 @default.
• W2152510114 cites W2075329854 @default.
• W2152510114 cites W2076849054 @default.
• W2152510114 cites W2077689433 @default.
• W2152510114 cites W2079132059 @default.
• W2152510114 cites W2080124363 @default.
• W2152510114 cites W2081884376 @default.
• W2152510114 cites W2088858763 @default.
• W2152510114 cites W2090670937 @default.
• W2152510114 cites W2094867990 @default.
• W2152510114 cites W2113319573 @default.
• W2152510114 cites W2121349506 @default.
• W2152510114 cites W2126985964 @default.
• W2152510114 cites W2137260811 @default.
• W2152510114 cites W2143005970 @default.
• W2152510114 cites W2145303760 @default.
• W2152510114 cites W2147979002 @default.
• W2152510114 cites W2148244829 @default.
• W2152510114 cites W2148684210 @default.
• W2152510114 cites W2150536104 @default.
• W2152510114 cites W2157046451 @default.
• W2152510114 cites W2157397597 @default.
• W2152510114 cites W2159289986 @default.
• W2152510114 cites W2166676855 @default.
• W2152510114 cites W2167045537 @default.
• W2152510114 cites W2168351979 @default.
• W2152510114 cites W2188234927 @default.
• W2152510114 cites W2332440185 @default.
• W2152510114 cites W31267017 @default.
• W2152510114 cites W3165324349 @default.
• W2152510114 cites W4231499941 @default.
• W2152510114 doi "https://doi.org/10.1002/path.2665" @default.
• W2152510114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20077527" @default.
• W2152510114 hasPublicationYear "2009" @default.
• W2152510114 type Work @default.
• W2152510114 sameAs 2152510114 @default.
• W2152510114 citedByCount "51" @default.
• W2152510114 countsByYear W21525101142012 @default.
• W2152510114 countsByYear W21525101142013 @default.
• W2152510114 countsByYear W21525101142014 @default.
• W2152510114 countsByYear W21525101142015 @default.
• W2152510114 countsByYear W21525101142016 @default.
• W2152510114 countsByYear W21525101142017 @default.
• W2152510114 countsByYear W21525101142018 @default.
• W2152510114 countsByYear W21525101142019 @default.
• W2152510114 countsByYear W21525101142021 @default.

• next