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- W2152546397 endingPage "459" @default.
- W2152546397 startingPage "447" @default.
- W2152546397 abstract "P-glycoprotein actively transports structurally unrelated compounds out of cells, conferring the multidrug resistance phenotype in cancer. Tariquidar is a potent, specific, noncompetitive inhibitor of P-glycoprotein. Tariquidar inhibits the ATPase activity of P-glycoprotein, suggesting that the modulating effect is derived from the inhibition of substrate binding, inhibition of ATP hydrolysis or both. In clinical trials, tariquidar is tolerable and does not have significant pharmacokinetic interaction with chemotherapy. In patients, inhibition of P-glycoprotein has been demonstrated for 48 h after a single dose of tariquidar. Studies to assess a possible increase in toxicity of chemotherapy and the impact of P-glycoprotein inhibition on tumor response and patient outcome are ongoing. Tariquidar can be considered an ideal agent for testing the role of P-glycoprotein inhibition in cancer." @default.
- W2152546397 created "2016-06-24" @default.
- W2152546397 creator A5013592290 @default.
- W2152546397 creator A5050738935 @default.
- W2152546397 date "2007-04-01" @default.
- W2152546397 modified "2023-10-14" @default.
- W2152546397 title "Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor" @default.
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- W2152546397 doi "https://doi.org/10.1586/14737140.7.4.447" @default.
- W2152546397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17428165" @default.
- W2152546397 hasPublicationYear "2007" @default.
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