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- W2152556985 endingPage "67" @default.
- W2152556985 startingPage "454" @default.
- W2152556985 abstract "Neurotrophins belonging to the class of growth factors and including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5) are widely recognized as essential factors in the developing central nervous system (CNS). Neurotrophins are synthesized as precursor forms (proneurotrophins). Mature forms of neurotrophins exert their effect by binding to specific tyrosine kinases receptors (TrkA, TrkB and TrkC) as well as via the p75 receptor, a member of the tumor necrosis factor receptor superfamily while proneurotrophins interact with the receptor p75 or co-receptor complex of p75 and sortilin, that is a Vps10p domain-containing transmembrane protein. Expression of neurotrophins corresponds with the onset of neurogenesis in developing mammalian species. BDNF is low in early embryonic stages of development, while NT-3 highly expresses in the developing CNS. Expression of neurotrophins receptors mainly overlaps at early development. Data concerning early distribution of neurotrophins and their receptors in the nervous system and results in mice with targeted disruptions of neurotrophin or receptor genes show that neurotrophins and their receptors play distinct roles in control and regulation of the most crucial developmental processes such as proliferation, migration, differentiation, survival, apoptosis and synaptic plasticity." @default.
- W2152556985 created "2016-06-24" @default.
- W2152556985 creator A5002436875 @default.
- W2152556985 creator A5052435991 @default.
- W2152556985 creator A5075143761 @default.
- W2152556985 date "2010-01-01" @default.
- W2152556985 modified "2023-09-29" @default.
- W2152556985 title "Neurotrophins and their receptors in early development of the mammalian nervous system." @default.
- W2152556985 cites W1481381242 @default.
- W2152556985 cites W1527035699 @default.
- W2152556985 cites W1563534485 @default.
- W2152556985 cites W1575648595 @default.
- W2152556985 cites W1783473189 @default.
- W2152556985 cites W1832821166 @default.
- W2152556985 cites W1880716631 @default.
- W2152556985 cites W1898295630 @default.
- W2152556985 cites W1927096988 @default.
- W2152556985 cites W1941281848 @default.
- W2152556985 cites W1966917600 @default.
- W2152556985 cites W1967336797 @default.
- W2152556985 cites W1969349734 @default.
- W2152556985 cites W1969479602 @default.
- W2152556985 cites W1972137168 @default.
- W2152556985 cites W1974539706 @default.
- W2152556985 cites W1977453394 @default.
- W2152556985 cites W1979405446 @default.
- W2152556985 cites W1981288686 @default.
- W2152556985 cites W1982892728 @default.
- W2152556985 cites W1984124075 @default.
- W2152556985 cites W1985822867 @default.
- W2152556985 cites W198779817 @default.
- W2152556985 cites W1990216950 @default.
- W2152556985 cites W1990311482 @default.
- W2152556985 cites W1990315686 @default.
- W2152556985 cites W1991561787 @default.
- W2152556985 cites W1995974861 @default.
- W2152556985 cites W1996052713 @default.
- W2152556985 cites W2001844599 @default.
- W2152556985 cites W2002758655 @default.
- W2152556985 cites W2004107819 @default.
- W2152556985 cites W2004552741 @default.
- W2152556985 cites W2004736079 @default.
- W2152556985 cites W2005288981 @default.
- W2152556985 cites W2011383191 @default.
- W2152556985 cites W2012332792 @default.
- W2152556985 cites W2013234569 @default.
- W2152556985 cites W2014871698 @default.
- W2152556985 cites W2015241504 @default.
- W2152556985 cites W2016531147 @default.
- W2152556985 cites W2020215900 @default.
- W2152556985 cites W2020441411 @default.
- W2152556985 cites W2020667484 @default.
- W2152556985 cites W2021656056 @default.
- W2152556985 cites W2026588006 @default.
- W2152556985 cites W2026958123 @default.
- W2152556985 cites W2028204690 @default.
- W2152556985 cites W2029447327 @default.
- W2152556985 cites W2033744604 @default.
- W2152556985 cites W2038842523 @default.
- W2152556985 cites W2038913473 @default.
- W2152556985 cites W2039812926 @default.
- W2152556985 cites W2039920787 @default.
- W2152556985 cites W2040135142 @default.
- W2152556985 cites W2040742427 @default.
- W2152556985 cites W2046829371 @default.
- W2152556985 cites W2047961162 @default.
- W2152556985 cites W2054354916 @default.
- W2152556985 cites W2055564874 @default.
- W2152556985 cites W2057144428 @default.
- W2152556985 cites W2060420333 @default.
- W2152556985 cites W2061050597 @default.
- W2152556985 cites W2061175787 @default.
- W2152556985 cites W2061599847 @default.
- W2152556985 cites W2063864897 @default.
- W2152556985 cites W2065329406 @default.
- W2152556985 cites W2066728536 @default.
- W2152556985 cites W2068968489 @default.
- W2152556985 cites W2070853081 @default.
- W2152556985 cites W2071867041 @default.
- W2152556985 cites W2071879765 @default.
- W2152556985 cites W2074200701 @default.
- W2152556985 cites W2075943597 @default.
- W2152556985 cites W2076037637 @default.
- W2152556985 cites W2076894554 @default.
- W2152556985 cites W2078316783 @default.
- W2152556985 cites W2080376521 @default.
- W2152556985 cites W2081975691 @default.
- W2152556985 cites W2085631765 @default.
- W2152556985 cites W2087090756 @default.
- W2152556985 cites W2089682627 @default.
- W2152556985 cites W2091448816 @default.
- W2152556985 cites W2092771994 @default.
- W2152556985 cites W2093089884 @default.
- W2152556985 cites W2093421538 @default.
- W2152556985 cites W2095294150 @default.
- W2152556985 cites W2106638431 @default.
- W2152556985 cites W2109124209 @default.
- W2152556985 cites W2110627100 @default.