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• W2152564006 startingPage "1048" @default.
• W2152564006 abstract "6-Phenylpyrrolocytidine (PhpC), a structurally conservative and highly fluorescent cytidine analog, was incorporated into oligoribonucleotides. The PhpC-containing RNA formed native-like duplex structures with complementary DNA or RNA. The PhpC-modification was found to act as a sensitive reporter group being non-disruptive to structure and the enzymatic activity of RNase H. A RNA/DNA hybrid possessing a single PhpC insert was an excellent substrate for HIV-1 RT Ribonuclease H and rapidly reported cleavage of the RNA strand with a 14-fold increase in fluorescence intensity. The PhpC-based assay for RNase H was superior to the traditional molecular beacon approach in terms of responsiveness, rapidity and ease (single label versus dual). Furthermore, the PhpC-based assay is amenable to high-throughput microplate assay format and may form the basis for a new screen for inhibitors of HIV-RT RNase H." @default.
• W2152564006 created "2016-06-24" @default.
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• W2152564006 creator A5054595603 @default.
• W2152564006 creator A5056069483 @default.
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• W2152564006 date "2009-11-20" @default.
• W2152564006 modified "2023-10-07" @default.
• W2152564006 title "A single-label phenylpyrrolocytidine provides a molecular beacon-like response reporting HIV-1 RT RNase H activity" @default.
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• W2152564006 doi "https://doi.org/10.1093/nar/gkp1022" @default.
• W2152564006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2817455" @default.
• W2152564006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19933258" @default.
• W2152564006 hasPublicationYear "2009" @default.
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