Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152593107> ?p ?o ?g. }
- W2152593107 endingPage "8983" @default.
- W2152593107 startingPage "8970" @default.
- W2152593107 abstract "During the development of the somatic genome from the Paramecium germline genome the bulk of the copies of ∼45 000 unique, internal eliminated sequences (IESs) are deleted. IES targeting is facilitated by two small RNA (sRNA) classes: scnRNAs, which relay epigenetic information from the parental nucleus to the developing nucleus, and iesRNAs, which are produced and used in the developing nucleus. Why only certain IESs require sRNAs for their removal has been enigmatic. By analyzing the silencing effects of three genes: PGM (responsible for DNA excision), DCL2/3 (scnRNA production) and DCL5 (iesRNA production), we identify key properties required for IES elimination. Based on these results, we propose that, depending on the exact combination of their lengths and end bases, some IESs are less efficiently recognized or excised and have a greater requirement for targeting by scnRNAs and iesRNAs. We suggest that the variation in IES retention following silencing of DCL2/3 is not primarily due to scnRNA density, which is comparatively uniform relative to IES retention, but rather the genetic properties of IESs. Taken together, our analyses demonstrate that in Paramecium the underlying genetic properties of developmentally deleted DNA sequences are essential in determining the sensitivity of these sequences to epigenetic control." @default.
- W2152593107 created "2016-06-24" @default.
- W2152593107 creator A5023278548 @default.
- W2152593107 creator A5025174656 @default.
- W2152593107 creator A5026392143 @default.
- W2152593107 creator A5044653915 @default.
- W2152593107 creator A5044820964 @default.
- W2152593107 creator A5066016728 @default.
- W2152593107 date "2014-07-12" @default.
- W2152593107 modified "2023-10-18" @default.
- W2152593107 title "Genome-wide analysis of genetic and epigenetic control of programmed DNA deletion" @default.
- W2152593107 cites W1602905276 @default.
- W2152593107 cites W1829692568 @default.
- W2152593107 cites W1946483892 @default.
- W2152593107 cites W1956129789 @default.
- W2152593107 cites W1963781146 @default.
- W2152593107 cites W1965124661 @default.
- W2152593107 cites W1965561195 @default.
- W2152593107 cites W1973435901 @default.
- W2152593107 cites W1973960846 @default.
- W2152593107 cites W1974520041 @default.
- W2152593107 cites W1978233528 @default.
- W2152593107 cites W1982808909 @default.
- W2152593107 cites W1990819915 @default.
- W2152593107 cites W1993527455 @default.
- W2152593107 cites W1995875735 @default.
- W2152593107 cites W1996832056 @default.
- W2152593107 cites W2008906567 @default.
- W2152593107 cites W2009957319 @default.
- W2152593107 cites W2017083894 @default.
- W2152593107 cites W2017972411 @default.
- W2152593107 cites W2022264984 @default.
- W2152593107 cites W2028839461 @default.
- W2152593107 cites W2028951414 @default.
- W2152593107 cites W2033983784 @default.
- W2152593107 cites W2037108634 @default.
- W2152593107 cites W2039596689 @default.
- W2152593107 cites W2041402229 @default.
- W2152593107 cites W2042836025 @default.
- W2152593107 cites W2042988618 @default.
- W2152593107 cites W2048402188 @default.
- W2152593107 cites W2054268736 @default.
- W2152593107 cites W2059864757 @default.
- W2152593107 cites W2063976281 @default.
- W2152593107 cites W2064560920 @default.
- W2152593107 cites W2070939744 @default.
- W2152593107 cites W2073403450 @default.
- W2152593107 cites W2077906468 @default.
- W2152593107 cites W2085085592 @default.
- W2152593107 cites W2086983477 @default.
- W2152593107 cites W2092501114 @default.
- W2152593107 cites W2095724228 @default.
- W2152593107 cites W2099800325 @default.
- W2152593107 cites W2103441770 @default.
- W2152593107 cites W2103676289 @default.
- W2152593107 cites W2104772148 @default.
- W2152593107 cites W2107356537 @default.
- W2152593107 cites W2107979888 @default.
- W2152593107 cites W2108234281 @default.
- W2152593107 cites W2109234767 @default.
- W2152593107 cites W2110491192 @default.
- W2152593107 cites W2122087169 @default.
- W2152593107 cites W2123982764 @default.
- W2152593107 cites W2125764601 @default.
- W2152593107 cites W2126696054 @default.
- W2152593107 cites W2128125656 @default.
- W2152593107 cites W2133749577 @default.
- W2152593107 cites W2141818629 @default.
- W2152593107 cites W2144993001 @default.
- W2152593107 cites W2145264494 @default.
- W2152593107 cites W2146443183 @default.
- W2152593107 cites W2154693022 @default.
- W2152593107 cites W2158266834 @default.
- W2152593107 cites W2162445149 @default.
- W2152593107 cites W2162896462 @default.
- W2152593107 cites W2167527994 @default.
- W2152593107 cites W2168015856 @default.
- W2152593107 cites W2170297435 @default.
- W2152593107 cites W2171560333 @default.
- W2152593107 cites W2271385996 @default.
- W2152593107 cites W31992746 @default.
- W2152593107 cites W4232332705 @default.
- W2152593107 cites W4233199237 @default.
- W2152593107 doi "https://doi.org/10.1093/nar/gku619" @default.
- W2152593107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4132734" @default.
- W2152593107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25016527" @default.
- W2152593107 hasPublicationYear "2014" @default.
- W2152593107 type Work @default.
- W2152593107 sameAs 2152593107 @default.
- W2152593107 citedByCount "34" @default.
- W2152593107 countsByYear W21525931072014 @default.
- W2152593107 countsByYear W21525931072015 @default.
- W2152593107 countsByYear W21525931072016 @default.
- W2152593107 countsByYear W21525931072017 @default.
- W2152593107 countsByYear W21525931072018 @default.
- W2152593107 countsByYear W21525931072019 @default.
- W2152593107 countsByYear W21525931072020 @default.
- W2152593107 countsByYear W21525931072021 @default.