FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152607871> ?p ?o ?g. }

• W2152607871 endingPage "204" @default.
• W2152607871 startingPage "197" @default.
• W2152607871 abstract "Hepatocellular carcinoma (HCC) is one of the most common cancers with a high mortality rate. Constitutive activation of STAT3 is found in various types of tumors, including HCC. In addition, suppressors of cytokine signaling 3 (SOCS3) signals for negative feedback to STATs, and is found to be inversely correlated with STAT3 expression. However, the exact role of SOCS3 in the tumorigenesis and progression of HCC is not fully understood. In this study we intended to show that SOCS3 inhibition promotes proliferation, migration, and invasion of HCC cells. HepG2, a human HCC cell line, was grown with SOCS3 siRNA or negative control (NC) transfection to assess the involvement of SOCS3 in cell proliferation, migration, and invasion by MTT, migration, and invasion assays, respectively. Western blot analysis was performed to examine the expression of STAT3, SOCS3, c-myc, matrix metalloproteinase (MMP)-2, and MMP-9 after transfection with either SOCS3 or NC siRNAs. A diethylnitrosamine (DEN)-induced HCC mouse model was assessed with or without injection of NSC 74859, a STAT3 inhibitor, to show accompanied changes among the expressions of STAT3, SOCS3, c-myc, MMP-2, and MMP-9. Inhibition of SOCS3 expression promoted the proliferation, migration, and invasion of HepG2 cells and increased the expression of c-myc, MMP-2, and MMP-9. HCC tumors developed in mice by DEN-induction with administration of NSC 74859 resulted in decreased expression of c-myc, MMP-2, and MMP-9, but not SOCS3. Loss of SOCS3 increased tumor growth, migration, and invasion and resulted in accompanied changes in expression of STAT3 and its target oncoproteins." @default.
• W2152607871 created "2016-06-24" @default.
• W2152607871 creator A5000891940 @default.
• W2152607871 creator A5019926568 @default.
• W2152607871 creator A5064402577 @default.
• W2152607871 creator A5072466648 @default.
• W2152607871 creator A5088541895 @default.
• W2152607871 date "2014-01-29" @default.
• W2152607871 modified "2023-10-16" @default.
• W2152607871 title "Loss of Suppressors of Cytokine Signaling 3 Promotes Aggressiveness in Hepatocellular Carcinoma" @default.
• W2152607871 cites W168754456 @default.
• W2152607871 cites W1851251844 @default.
• W2152607871 cites W1913696895 @default.
• W2152607871 cites W1971095820 @default.
• W2152607871 cites W1973008001 @default.
• W2152607871 cites W1973514550 @default.
• W2152607871 cites W1988719795 @default.
• W2152607871 cites W1996112634 @default.
• W2152607871 cites W2000307707 @default.
• W2152607871 cites W2009500547 @default.
• W2152607871 cites W2013691481 @default.
• W2152607871 cites W2017228430 @default.
• W2152607871 cites W2024282024 @default.
• W2152607871 cites W2025987977 @default.
• W2152607871 cites W2028979785 @default.
• W2152607871 cites W2029462907 @default.
• W2152607871 cites W2030491592 @default.
• W2152607871 cites W2033621350 @default.
• W2152607871 cites W2035116915 @default.
• W2152607871 cites W2040002852 @default.
• W2152607871 cites W2043758117 @default.
• W2152607871 cites W2053951934 @default.
• W2152607871 cites W2065676042 @default.
• W2152607871 cites W2067224679 @default.
• W2152607871 cites W2069683822 @default.
• W2152607871 cites W2074356752 @default.
• W2152607871 cites W2077939167 @default.
• W2152607871 cites W2078308735 @default.
• W2152607871 cites W2081003617 @default.
• W2152607871 cites W2088089867 @default.
• W2152607871 cites W2098387743 @default.
• W2152607871 cites W2105398918 @default.
• W2152607871 cites W2107459338 @default.
• W2152607871 cites W2131666890 @default.
• W2152607871 cites W2137135537 @default.
• W2152607871 cites W2149560261 @default.
• W2152607871 cites W2155541598 @default.
• W2152607871 cites W2160512993 @default.
• W2152607871 cites W2162319521 @default.
• W2152607871 cites W2163406329 @default.
• W2152607871 cites W2165174685 @default.
• W2152607871 cites W2321119966 @default.
• W2152607871 cites W2332528102 @default.
• W2152607871 doi "https://doi.org/10.3109/08941939.2013.873098" @default.
• W2152607871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24476004" @default.
• W2152607871 hasPublicationYear "2014" @default.
• W2152607871 type Work @default.
• W2152607871 sameAs 2152607871 @default.
• W2152607871 citedByCount "15" @default.
• W2152607871 countsByYear W21526078712015 @default.
• W2152607871 countsByYear W21526078712016 @default.
• W2152607871 countsByYear W21526078712017 @default.
• W2152607871 countsByYear W21526078712019 @default.
• W2152607871 countsByYear W21526078712020 @default.
• W2152607871 countsByYear W21526078712021 @default.
• W2152607871 countsByYear W21526078712022 @default.
• W2152607871 crossrefType "journal-article" @default.
• W2152607871 hasAuthorship W2152607871A5000891940 @default.
• W2152607871 hasAuthorship W2152607871A5019926568 @default.
• W2152607871 hasAuthorship W2152607871A5064402577 @default.
• W2152607871 hasAuthorship W2152607871A5072466648 @default.
• W2152607871 hasAuthorship W2152607871A5088541895 @default.
• W2152607871 hasConcept C109523444 @default.
• W2152607871 hasConcept C121608353 @default.
• W2152607871 hasConcept C126042315 @default.
• W2152607871 hasConcept C126322002 @default.
• W2152607871 hasConcept C137738243 @default.
• W2152607871 hasConcept C203014093 @default.
• W2152607871 hasConcept C22615655 @default.
• W2152607871 hasConcept C2775965246 @default.
• W2152607871 hasConcept C2778019345 @default.
• W2152607871 hasConcept C2778690821 @default.
• W2152607871 hasConcept C2778923194 @default.
• W2152607871 hasConcept C502942594 @default.
• W2152607871 hasConcept C54009773 @default.
• W2152607871 hasConcept C54355233 @default.
• W2152607871 hasConcept C555283112 @default.
• W2152607871 hasConcept C62112901 @default.
• W2152607871 hasConcept C62478195 @default.
• W2152607871 hasConcept C71924100 @default.
• W2152607871 hasConcept C81885089 @default.
• W2152607871 hasConcept C86803240 @default.
• W2152607871 hasConcept C95444343 @default.
• W2152607871 hasConceptScore W2152607871C109523444 @default.
• W2152607871 hasConceptScore W2152607871C121608353 @default.
• W2152607871 hasConceptScore W2152607871C126042315 @default.
• W2152607871 hasConceptScore W2152607871C126322002 @default.
• W2152607871 hasConceptScore W2152607871C137738243 @default.

• next