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• W2152613468 abstract "A family of microtubule (MT)-binding proteins, Orbit/multiple asters/cytoplasmic linker protein-associated protein, has emerged as an important player during mitosis, but their functional mechanisms are poorly understood. In this study, we used meiotic egg extracts to gain insight into the role of the Xenopus laevis homologue Xorbit in spindle assembly and function. Xorbit immunodepletion or its inhibition by a dominant-negative fragment resulted in chromosome alignment defects and aberrant MT structures, including monopolar and small spindles. Xorbit-depleted extracts failed to nucleate MTs around chromatin-coated beads, indicating its essential requirement for spindle assembly in the absence of centrosomes and kinetochores. Xorbit's MT stabilizing effect was most apparent during anaphase, when spindle MTs depolymerized rapidly upon Xorbit inhibition. Biochemical interaction between a COOH-terminal Xorbit fragment and the kinetochore-associated kinesin centromeric protein E may contribute to Xorbit's role in chromosome congression. We propose that Xorbit tethers dynamic MT plus ends to kinetochores and chromatin, providing a stabilizing activity that is crucial for spindle assembly and chromosome segregation." @default.
• W2152613468 created "2016-06-24" @default.
• W2152613468 creator A5022379698 @default.
• W2152613468 creator A5050477139 @default.
• W2152613468 date "2006-01-02" @default.
• W2152613468 modified "2023-09-25" @default.
• W2152613468 title "Xorbit/CLASP links dynamic microtubules to chromosomes in the <i>Xenopus</i> meiotic spindle" @default.
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• W2152613468 doi "https://doi.org/10.1083/jcb.200508180" @default.
• W2152613468 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2063525" @default.
• W2152613468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16390996" @default.
• W2152613468 hasPublicationYear "2006" @default.
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