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- W2152635629 abstract "Enhancer-blocking insulators are DNA elements that disrupt the communication between a regulatory sequence, such as an enhancer or a silencer, and a promoter. Insulators participate in both transcriptional regulation and global nuclear organization, two features of chromatin that are thought to be maintained from one generation to the next through epigenetic mechanisms. Furthermore, there are many regulatory mechanisms in place that enhance or hinder insulator activity. These modes of regulation could be used to establish cell-type-specific insulator activity that is epigenetically inherited along a cell and/or organismal lineage. This review will discuss the evidence for epigenetic inheritance and regulation of insulator function." @default.
- W2152635629 created "2016-06-24" @default.
- W2152635629 creator A5027065390 @default.
- W2152635629 creator A5082436986 @default.
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- W2152635629 date "2008-10-01" @default.
- W2152635629 modified "2023-10-10" @default.
- W2152635629 title "Chromatin Insulators: Regulatory Mechanisms and Epigenetic Inheritance" @default.
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- W2152635629 doi "https://doi.org/10.1016/j.molcel.2008.08.017" @default.
- W2152635629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2576288" @default.
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