Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152642144> ?p ?o ?g. }
- W2152642144 abstract "DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning, cell specificity, and dynamics of DNA methylation at single-base resolution in human and mouse frontal cortex throughout their lifespan. Widespread methylome reconfiguration occurs during fetal to young adult development, coincident with synaptogenesis. During this period, highly conserved non-CG methylation (mCH) accumulates in neurons, but not glia, to become the dominant form of methylation in the human neuronal genome. Moreover, we found an mCH signature that identifies genes escaping X-chromosome inactivation. Last, whole-genome single-base resolution 5-hydroxymethylcytosine (hmC) maps revealed that hmC marks fetal brain cell genomes at putative regulatory regions that are CG-demethylated and activated in the adult brain and that CG demethylation at these hmC-poised loci depends on Tet2 activity." @default.
- W2152642144 created "2016-06-24" @default.
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- W2152642144 date "2013-08-09" @default.
- W2152642144 modified "2023-10-17" @default.
- W2152642144 title "Global Epigenomic Reconfiguration During Mammalian Brain Development" @default.
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